dihydroorotase
Sign in to saveAlso known as carbamoylaspartic dehydrase, (S)-dihydroorotate amidohydrolase, dihydroorotate hydrolase, DHOase
Dihydroorotase (, carbamoylaspartic dehydrase, dihydroorotate hydrolase) is an enzyme which converts carbamoyl aspartic acid into 4,5-dihydroorotic acid in the biosynthesis of pyrimidines. It forms a multifunctional enzyme with carbamoyl phosphate synthetase and aspartate transcarbamoylase. Dihydroorotase is a zinc metalloenzyme.
In the Vinony graph
Within Vinony's link graph, dihydroorotase is referenced by 309 other articles, and connects out to Aspartate carbamoyltransferase, pyrimidine nucleotide metabolic process and activation induced cytidine deaminase.
Vinony files it under EC 3.5.2 and Genes on human chromosome 2.
Its subject is documented across 10 Wikipedia language editions.
Research
649 papers- Crystal structure of Methanococcus jannaschii dihydroorotase.Proteins · 2023
- Dihydroorotase MoPyr4 is required for development, pathogenicity, and autophagy in rice blast fungus.Cell communication and signaling : CCS · 2024
- The Loop-In Binding Mode of Dihydroorotase: Implications for Ligand Binding and Therapeutic Targeting.International journal of molecular sciences · 2025
- Functional analyses of Toxoplasma gondii dihydroorotase reveal a promising anti-parasitic target.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
- Pyrimidine biosynthesis.The American journal of clinical nutrition · 1979
via PubMed
Wikidata facts
- Subclass of
- amidohydrolases
- Image
- 4by3.jpg
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- EC enzyme number
- 3.5.2.3
- Commons category
- Dihydroorotase
Sources (2)
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Encyclopedic overview
3 sectionsContents
- See also
- References
- External links
Dihydroorotase (, carbamoylaspartic dehydrase, dihydroorotate hydrolase) is an enzyme which converts carbamoyl aspartic acid into 4,5-dihydroorotic acid in the biosynthesis of pyrimidines. It forms a multifunctional enzyme with carbamoyl phosphate synthetase and aspartate transcarbamoylase. Dihydroorotase is a zinc metalloenzyme.
== See also == Pyrimidine biosynthesis
Excerpted from Wikipedia’s “dihydroorotase” article, available under the CC BY-SA 4.0 licence.