Structure via PubChem · Public domain (PubChem)
dimethisoquin
Sign in to saveAlso known as quinisocaine
Quinisocaine (INN) or dimethisoquin (BAN and USAN) is a topical anesthetic used as an antipruritic.
Chemical data
- Formula
- C17H24N2O
- Molecular weight
- 272.4 g/mol
- IUPAC name
- 2-(3-butylisoquinolin-1-yl)oxy-N,N-dimethylethanamine
- SMILES
- CCCCC1=CC2=CC=CC=C2C(=N1)OCCN(C)C
- InChIKey
- XNMYNYSCEJBRPZ-UHFFFAOYSA-N
- XLogP
- 4.2
- Polar surface area
- 25.4 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- Pruritus
via ChEMBL · EBI
Research
11 papers- Travell trigger points--molecular and osteopathic perspectives.The Journal of the American Osteopathic Association · 2004
- Local anesthetics noncompetitively inhibit function of four distinct nicotinic acetylcholine receptor subtypes.The Journal of pharmacology and experimental therapeutics · 2001
- Use of dimethisoquin in pruritic dermatoses: a three year study.Southern medical journal · 1957
- Desensitization of membrane-bound Torpedo acetylcholine receptor by amine noncompetitive antagonists and aliphatic alcohols: studies of [3H]acetylcholine binding and 22Na+ ion fluxes.Biochemistry · 1984
- Effects of local anesthetics and histrionicotoxin on the binding of carbamoylcholine to membrane-bound acetylcholine receptor.Biochemistry · 1981
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 272.189
Show 4 more facts
- chemical formula
- C₁₇H₂₄N₂O
- canonical SMILES
- CCCCC1=CC2=CC=CC=C2C(=N1)OCCN(C)C
- subject has role
- local anesthetic
- Commons category
- Quinisocaine
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
Quinisocaine (INN) or dimethisoquin (BAN and USAN) is a topical anesthetic used as an antipruritic.
==Synthesis== [[File:Quinisocaine synthesis.svg|thumb|center|700px|class=skin-invert-image|Thieme Synthesis: Patent:]]
Excerpted from Wikipedia’s “dimethisoquin” article, available under the CC BY-SA 4.0 licence.