DNMT3A
Sign in to saveAlso known as DNMT3A2, M.HsaIIIA, TBRS, DNA (cytosine-5-)-methyltransferase 3 alpha, DNA methyltransferase 3 alpha, HESJAS
protein-coding gene in the species Homo sapiens
Gene data
DNMT3A- Name
- DNA methyltransferase 3 alpha
- Type
- protein-coding
- Position
- 25,227,855–25,342,590 (−)
- Aliases
- DNMT3A2, HESJAS, M.HsaIIIA, TBRS
- Ensembl
- ENSG00000119772
- RefSeq RNA
- NM_001320892.2, NM_001320893.1, NM_001375819.1, NM_022552.5, NM_153759.3
- RefSeq protein
- NP_001307821.1, NP_001307822.1, NP_001362748.1, NP_072046.2, NP_715640.2
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
DNA methyltransferase 3 alpha
- Symbol
- DNMT3A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:25,227,855-25,342,590
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein DNMT3A PDB 2QRV.png
Show 5 more facts
- HomoloGene ID
- 7294
- genomic end
- 25565459
- exact match
- identifiers.org/ncbigene/1788
- genomic start
- 25455845
- cytogenetic location
- 2p23.3
via Wikidata · CC0