DNMT3A

Name

DNA methyltransferase 3 alpha

Type

protein-coding

Position

25,227,855–25,342,590 (−)

Aliases

DNMT3A2, HESJAS, M.HsaIIIA, TBRS

Ensembl

ENSG00000119772

RefSeq RNA

NM_001320892.2, NM_001320893.1, NM_001375819.1, NM_022552.5, NM_153759.3

RefSeq protein

NP_001307821.1, NP_001307822.1, NP_001362748.1, NP_072046.2, NP_715640.2

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016].