Structure via PubChem · Public domain (PubChem)
doxazosin
Sign in to saveAlso known as UK-3327427, 1-(4-amino-6,7-dimethoxy-2-chinazolinyl)-4-(2,3-dihydro-1,4-benzodioxixin-2-ylcarbonyl)piperazin, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazin
Chemical data
- Formula
- C23H25N5O5
- Molecular weight
- 451.5 g/mol
- IUPAC name
- [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone
- SMILES
- COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
- InChIKey
- RUZYUOTYCVRMRZ-UHFFFAOYSA-N
- XLogP
- 2.5
- Polar surface area
- 112 Ų
- H-bond donors
- 1
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Research
2,084 papers- Doxazosin Attenuates Liver Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via Activation of the PI3K/Akt/mTOR Signaling Pathway.Drug design, development and therapy · 2021
- Doxazosin and congestive heart failure.Congestive heart failure (Greenwich, Conn.) · 2002
- Doxazosin in the current treatment of hypertension.Expert opinion on pharmacotherapy · 2008
- Doxazosin gastrointestinal therapeutic system: a review of its use in benign prostatic hyperplasia.Drugs · 2005
- Doxazosin in the treatment of benign prostatic hypertrophy: an update.Clinical interventions in aging · 2006
via PubMed
Wikidata facts
- Subclass of
- medication
- Mass
- 451.185569
Show 8 more facts
- chemical formula
- C₂₃H₂₅N₅O₅
- subject has role
- alpha blocker
- medical condition treated
- arterial hypertension
- canonical SMILES
- COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
- World Health Organisation international non-proprietary name
- doxazosin
- defined daily dose
- 4
- Commons category
- Doxazosin
- significant drug interaction
- levobunolol
Sources (7)
via Wikidata · CC0
~4 min read
Encyclopedic overview
11 sectionsContents
- Medical uses
- High blood pressure
- Benign prostatic hyperplasia
- PTSD nightmares and flashbacks
- Pharmacology
- History
- Society and culture
- Brand names
- Research
- See also
- References
Doxazosin, the brand name Cardura among others, is a medication used to treat symptoms of benign prostatic hyperplasia (enlarged prostate), hypertension (high blood pressure), and post-traumatic stress disorder (PTSD). For high blood pressure, it is a less preferred option. It is taken by mouth.
Common side effects include dizziness, sleepiness, swelling, nausea, shortness of breath, and abdominal pain. Severe side effects may include low blood pressure with standing, an irregular heart beat, and priapism. It is a selective α1-adrenergic blocker in the quinazoline class of compounds.
Excerpted from Wikipedia’s “doxazosin” article, available under the CC BY-SA 4.0 licence.