EDN2

Name

endothelin 2

Type

protein-coding

Position

41,478,774–41,484,686 (−)

Aliases

ET-2, ET2, PPET2

Ensembl

ENSG00000127129

RefSeq RNA

NM_001302269.2, NM_001956.5, NR_126098.2, XM_017000512.2, XM_054334817.1

RefSeq protein

NP_001289198.1, NP_001947.1, XP_016856001.2, XP_054190792.1, XP_054190793.1

This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].