EDN2
Sign in to saveAlso known as ET2, PPET2, ET-2, endothelin 2
protein-coding gene in the species Homo sapiens
Gene data
EDN2- Name
- endothelin 2
- Type
- protein-coding
- Position
- 41,478,774–41,484,686 (−)
- Aliases
- ET-2, ET2, PPET2
- Ensembl
- ENSG00000127129
- RefSeq RNA
- NM_001302269.2, NM_001956.5, NR_126098.2, XM_017000512.2, XM_054334817.1
- RefSeq protein
- NP_001289198.1, NP_001947.1, XP_016856001.2, XP_054190792.1, XP_054190793.1
This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
Gene Ontology
Biological process
angiogenesisvasculature developmentpositive regulation of leukocyte chemotaxishormonal regulation of the force of heart contractionpositive regulation of the force of heart contraction by chemical signalregulation of systemic arterial blood pressure by endothelinregulation of systemic arterial blood pressure by endothelinintracellular calcium ion homeostasis
Molecular function
Pathways
cAMP signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Vascular smooth muscle contraction - Homo sapiens (human)Renin secretion - Homo sapiens (human)Signal TransductionSignaling by GPCRClass A/1 (Rhodopsin-like receptors)Peptide ligand-binding receptorsGPCR downstream signallingG alpha (q) signalling events
via MyGene.info
Gene · Ensembl
endothelin 2
- Symbol
- EDN2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:41,478,774-41,500,502
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 1477
- exact match
- identifiers.org/ncbigene/1907
- genomic end
- 41484683
- genomic start
- 41944446
- cytogenetic location
- 1p34.2
Sources (4)
via Wikidata · CC0
Connections
Q180686
Entity
Ensembl genome database project
Entity
International Standard Book Number
Entity
Wikidata
Entity
gene
Entity
chromosome
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amino acid
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digital object identifier
Entity
breast cancer
Entity
ovary
Entity
immunology
Entity
phenotype
Entity
peptide
Entity
menstrual cycle
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biopsy
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apoptotic process
Entity
bibcode
Entity
ovulation
Entity
macrophage
Entity
nitric oxide
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