English

English Deutsch Español Français Italiano Nederlands Português Svenska العربية

GeneQ18034725· pop 7· linked from 6 articles

ELMO1

Sign in to save

Also known as CED-12, CED12, ELMO-1, engulfment and cell motility 1

Engulfment and cell motility protein 1 is a protein that in humans is encoded by the ELMO1 gene. ELMO1 is located on chromosome number seven in humans and is located on chromosome number thirteen in mice.

Gene data

ELMO1

Name: engulfment and cell motility 1
Type: protein-coding
Position: 36,852,906–37,449,435 (−)
Aliases: CED-12, CED12, ELMO-1
Ensembl: ENSG00000155849
RefSeq RNA: NM_001039459.3, NM_001206480.2, NM_001206482.2, NM_014800.11, NM_130442.4
RefSeq protein: NP_001034548.1, NP_001193409.1, NP_001193411.1, NP_055615.8, NP_569709.1

This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].

Gene Ontology

Biological process

phagocytosis, engulfment apoptotic process actin filament organization Rac protein signal transduction actin cytoskeleton organization cell motility cell chemotaxis

Molecular function

protein binding SH3 domain binding guanyl nucleotide exchange factor activator activity

Cellular component

cytoplasm cytoplasm cytosol plasma membrane plasma membrane plasma membrane membrane guanyl-nucleotide exchange factor complex

Pathways

Chemokine signaling pathway - Homo sapiens (human)Bacterial invasion of epithelial cells - Homo sapiens (human)Shigellosis - Homo sapiens (human)Salmonella infection - Homo sapiens (human)Yersinia infection - Homo sapiens (human)Cell-Cell communication Signal Transduction HIV Infection Host Interactions of HIV factors Disease

via MyGene.info

Gene · Ensembl

engulfment and cell motility 1

Symbol: ELMO1
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:36,852,906-37,449,435
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: 2VSZ.pdb1.png

Show 9 more facts

HomoloGene ID: 56685
genetic association: type 2 diabetes
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/9844
genomic end: 37449223
genomic start: 36852906
chromosome: human chromosome 7
cytogenetic location: 7p14.2-p14.1
expressed in: ganglionic eminence

Sources (5)

via Wikidata · CC0

~2 min read

Encyclopedic overview

5 sections

Contents

Structure
Function
Interactions
References
Further reading

Engulfment and cell motility protein 1 is a protein that in humans is encoded by the ELMO1 gene. ELMO1 is located on chromosome number seven in humans and is located on chromosome number thirteen in mice.

== Structure ==

Excerpted from Wikipedia’s “ELMO1” article, available under the CC BY-SA 4.0 licence.

Available in 7 languages

via Wikidata sitelinks · CC0