Enamelin
Sign in to saveAlso known as ENAM, amelogenesis imperfecta 2, hypocalcification (autosomal dominant)
Enamelin is an enamel matrix protein (EMPs), that in humans is encoded by the ENAM gene. It is part of the non-amelogenins, which comprise 10% of the total enamel matrix proteins. It is one of the key proteins thought to be involved in amelogenesis (enamel development). The formation of enamel's intricate architecture is thought to be rigorously controlled in ameloblasts through interactions of various organic matrix protein molecules that include: enamelin, amelogenin, ameloblastin, tuftelin, dentine sialophosphoprotein, and a variety of enzymes. Enamelin is the largest protein (~168kDa) in t
Protein · UniProt
Enamelin
- Gene
- ENAM
- Organism
- Homo sapiens (Human)
- Length
- 1,142 aa
- Molecular mass
- 128,785 Da
- Evidence
- 1: Evidence at protein level
Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
1 registered- COMPLETEDPolymorphisms in ENAM, AMBN, and KLK4 Contribute to DCS.Amina Fouad Farag · NCT06343766
~4 min read
Encyclopedic overview
7 sectionsContents
- Structure
- Function
- Clinical significance
- See also
- References
- Further reading
- External links
Enamelin is an enamel matrix protein (EMPs), that in humans is encoded by the ENAM gene. It is part of the non-amelogenins, which comprise 10% of the total enamel matrix proteins. It is one of the key proteins thought to be involved in amelogenesis (enamel development). The formation of enamel's intricate architecture is thought to be rigorously controlled in ameloblasts through interactions of various organic matrix protein molecules that include: enamelin, amelogenin, ameloblastin, tuftelin, dentine sialophosphoprotein, and a variety of enzymes. Enamelin is the largest protein (~168kDa) in the enamel matrix of developing teeth and is the least abundant (encompasses approximately 1-5%) of total enamel matrix proteins. It is present predominantly at the growing enamel surface.
== Structure == Enamelin is thought to be the oldest member of the enamel matrix protein (EMP) family, with animal studies showing remarkable conservation of the gene phylogenetically. All other EMPs are derived from enamelin, such as amelogenin. EMPs belong to a larger family of proteins termed 'secretory calcium-binding phosphoproteins' (SCPP).
Excerpted from Wikipedia’s “Enamelin” article, available under the CC BY-SA 4.0 licence.