enrofloxacin

Enrofloxacin, sold under the brand name Baytril, among others, is a fluoroquinolone antibiotic used for the treatment of animals. It is a bactericidal agent.

Chemical data

Formula: C19H22FN3O3
Molecular weight: 359.4 g/mol
IUPAC name: 1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxoquinoline-3-carboxylic acid
SMILES: CCN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4CC4)F
InChIKey: SPFYMRJSYKOXGV-UHFFFAOYSA-N
XLogP: -0.2
Polar surface area: 64.1 Å²
H-bond donors: 1
H-bond acceptors: 7
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule

via ChEMBL · EBI

Research

4,425 papers

The enrofloxacin pollution control from fish to environment.Marine pollution bulletin · 2024
Enrofloxacin-The Ruthless Killer of Eukaryotic Cells or the Last Hope in the Fight against Bacterial Infections?International journal of molecular sciences · 2022
Enrofloxacin-associated ocular disease in cats: A scoping review.The Canadian veterinary journal = La revue veterinaire canadienne · 2025
Enrofloxacin: pharmacokinetics and metabolism in domestic animal species.Current drug metabolism · 2013
Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin.Drug delivery · 2020

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 359.165

Show 5 more facts

chemical formula: C₁₉H₂₂FN₃O₃
canonical SMILES: CCN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4CC4)F
Commons category: Enrofloxacin
subject has role: antineoplastic
medical condition treated: bacterial infectious disease

Sources (5)

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Encyclopedic overview

5 sections

Contents

Activity and susceptibility data
Adverse effects/warnings
Overdosage/acute toxicity
Degradation
References

Enrofloxacin, sold under the brand name Baytril, among others, is a fluoroquinolone antibiotic used for the treatment of animals. It is a bactericidal agent.

The bactericidal activity of enrofloxacin is concentration-dependent, with susceptible bacteria cell death occurring within 20–30 minutes of exposure. Enrofloxacin has demonstrated a significant post-antibiotic effect for both Gram-negative and Gram-positive bacteria and is active in both stationary and growth phases of bacterial replication. Enrofloxacin is partially deethylated by CYP450 into the active metabolite ciprofloxacin, which is also a fluoroquinolone antibiotic.

Excerpted from Wikipedia’s “enrofloxacin” article, available under the CC BY-SA 4.0 licence.

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