eribulin

Also known as 2-(3-Amino-2-hydroxypropyl)hexacosahydro-3-methoxy- 26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy- 7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6) pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one, eribulin mesylate, L01XX41, ER-086526, E7389

Eribulin, sold under the brand name Halaven among others, is an anti-cancer medication used to treat breast cancer and liposarcoma.

In the Vinony graph

Vinony's link graph records 289 inbound references to eribulin, and connects out to chemotherapy, tiazofurin and International Standard Book Number.

Vinony files it under Amines, Antineoplastic drugs and Drugboxes which contain changes to verified fields.

Vinony links it to 18 Wikipedia language editions.

Key facts

Drug.Verifiedfields: changed
Drug.verifiedrevid: 461094948
Drug.image: Eribulin.svg
Drug.image_class: skin-invert-image
Drug.width: 300
Drug.USAN: eribulin mesylate
Drug.JAN: eribulin mesilate
Drug.tradename: Halaven, Mevlyq
Drug.MedlinePlus: a611007
Drug.DailyMedID: Eribulin
Drug.pregnancy_AU: D
Drug.routes_of_administration: Intravenous
Drug.class: Antineoplastic
Drug.ATC_prefix: L01
Drug.ATC_suffix: XX41
Drug.legal_AU: S4
Drug.legal_CA: Rx-only
Drug.legal_UK: POM

via Wikipedia infobox

Research

1,184 papers

Eribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma: a randomised, open-label, multicentre, phase 3 trial.Lancet (London, England) · 2016
Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study.Lancet (London, England) · 2011
Eribulin.Drugs · 2011
Eribulin in advanced liposarcoma and leiomyosarcoma.Expert review of anticancer therapy · 2017
Clinical and preclinical features of eribulin-related peripheral neuropathy.Experimental neurology · 2022

via PubMed

Wikidata facts

Mass: 729.409

Show 5 more facts

chemical formula: C₄₀H₅₉NO₁₁
isomeric SMILES: C[C@@H]1C[C@@H]2CC[C@H]3C(=C)C[C@@H](O3)CC[C@]45C[C@@H]6[C@H](O4)[C@H]7[C@@H](O6)[C@@H](O5)[C@@H]8[C@@H](O7)CC[C@@H](O8)CC(=O)C[C@H]9[C@H](C[C@H](C1=C)O2)O[C@@H]([C@@H]9OC)C[C@@H](CN)O
canonical SMILES: CC1CC2CCC3C(=C)CC(O3)CCC45CC6C(O4)C7C(O6)C(O5)C8C(O7)CCC(O8)CC(=O)CC9C(CC(C1=C)O2)OC(C9OC)CC(CN)O
stylized name: eriBULin
Commons category: Eribulin

Sources (7)

via Wikidata · CC0

~4 min read

Encyclopedic overview

5 sections

Contents

Medical uses
Adverse effects
Structure and mechanism
Research
References

Eribulin, sold under the brand name Halaven among others, is an anti-cancer medication used to treat breast cancer and liposarcoma.

The most common side effects include fatigue, nausea, hair loss (alopecia), constipation, certain nerve damage causing weakness or numbness in the hands and feet (peripheral neuropathy), abdominal pain and fever (pyrexia). Eribulin may also cause low levels of infection-fighting white blood cells (neutropenia) or decreased levels of potassium or calcium.

Excerpted from Wikipedia’s “eribulin” article, available under the CC BY-SA 4.0 licence.