etanercept
Sign in to saveAlso known as Rhu Tnfr, Fc, TNFR-immunoadhesin, p80 TNF-alpha receptor, CD120b, Tumor necrosis factor receptor type II, Tumor necrosis factor receptor 2, TNF-R2
Etanercept, sold under the brand name Enbrel among others, is a biologic medical product that is used to treat autoimmune diseases by interfering with tumor necrosis factor (TNF), a soluble inflammatory cytokine, by acting as a TNF inhibitor. It has US Food and Drug Administration (FDA) approval to treat rheumatoid arthritis, juvenile idiopathic arthritis and psoriatic arthritis, plaque psoriasis and ankylosing spondylitis. TNF is the "master regulator" of the inflammatory (immune) response in many organ systems. Autoimmune diseases are caused by an overactive immune response. Etanercept has t
Key facts
- Drug.legal_US
- Rx-only
- Drug.image
- Enbrel.jpg
- Drug.width
- 153
- Drug.tradename
- Enbrel
- Drug.MedlinePlus
- a602013
- Drug.DailyMedID
- Etanercept
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- Subcutaneous
- Drug.ATC_prefix
- L04
- Drug.ATC_suffix
- AB01
- Drug.biosimilars
- etanercept-szzs, etanercept-ykro, Benepali, Brenzys, Erelzi, Etacept, Etera, Eticovo, Lifmior, Nepexto, Rymti
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_CA_comment
- / Schedule D
- Drug.legal_UK
- POM
- Drug.legal_EU
- Rx-only
- Drug.bioavailability
- 58–76% (SC)
- Drug.elimination_half life
- 70–132 hours
via Wikipedia infobox
Research
10,434 papers- Etanercept biosimilar SB-4.Expert opinion on biological therapy · 2019
- Etanercept.Expert opinion on biological therapy · 2008
- Perispinal etanercept stroke trial design: PESTO and beyond.Expert opinion on biological therapy · 2024
- GP2015: An Etanercept Biosimilar.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2017
- Etanercept for treating axial spondyloarthritis.Expert opinion on biological therapy · 2017
via PubMed
Described at
Etanercept: uses & side-effects | PatientsLikeMe
Find treatment reviews for Etanercept from other patients. Learn from their experiences about effectiveness, side effects and cost
patientslikeme.com →Etanercept is an antirheumatic drug that helps block inflammation. It may be used to treat certain auto-immune conditions including rheumatoid arthritis, juvenile rheumatoid arthritis, psoriatic arthritis, plaque psoriasis, and ankylosing spondylitis.
Excerpt from a page describing this subject · 7,807 chars · not written by Vinony
Wikidata facts
- Image
- Etanercept.svg
Show 4 more facts
- Commons category
- Etanercept
- chemical formula
- C₂₂₂₄H₃₄₇₅N₆₂₁O₆₉₈S₃₆
- defined daily dose
- 7
- described at URL
- www.patientslikeme.com/treatment/etanercept
Sources (8)
via Wikidata · CC0
~9 min read
Article
11 sectionsContents
- Medical uses
- Unrecognized uses
- Adverse effects
- Mechanism of action
- Structure
- History
- Society and culture
- Economics
- Patents
- Biosimilars
- References
Etanercept, sold under the brand name Enbrel among others, is a biologic medical product that is used to treat autoimmune diseases by interfering with tumor necrosis factor (TNF), a soluble inflammatory cytokine, by acting as a TNF inhibitor. It has US Food and Drug Administration (FDA) approval to treat rheumatoid arthritis, juvenile idiopathic arthritis and psoriatic arthritis, plaque psoriasis and ankylosing spondylitis. TNF is the "master regulator" of the inflammatory (immune) response in many organ systems. Autoimmune diseases are caused by an overactive immune response. Etanercept has the potential to treat these diseases by inhibiting TNF.
Etanercept is a fusion protein produced by recombinant DNA. It fuses the TNF receptor to the constant end of the IgG1 antibody. First, the developers isolated the DNA sequence that codes the human gene for soluble TNF receptor 2, which is a receptor that binds to tumor necrosis factor. Second, they isolated the DNA sequence that codes the human gene for the Fc end of immunoglobulin G1 (IgG1). Third, they linked the DNA for TNF receptor 2 to the DNA for IgG1 Fc. Finally, they expressed the linked DNA to produce a protein that links the protein for TNF receptor 2 to the protein for IgG1 Fc.