FCHSD2

Also known as NWK, SH3MD3, FCH and double SH3 domains 2, NWK1

FCH and double SH3 domains protein 2 is a protein that in humans is encoded by the FCHSD2 gene.

Gene data

FCHSD2

Name: FCH and double SH3 domains 2
Type: protein-coding
Position: 72,836,742–73,142,346 (−)
Aliases: NWK, NWK1, SH3MD3
Ensembl: ENSG00000137478
RefSeq RNA: NM_014824.3, XM_011545409.2, XM_011545410.3, XM_047427949.1, XM_047427950.1
RefSeq protein: NP_055639.2, XP_011543711.1, XP_011543712.1, XP_047283905.1, XP_047283906.1

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in clathrin-dependent endocytosis and positive regulation of Arp2/3 complex-mediated actin nucleation. Located in plasma membrane. Colocalizes with clathrin-coated pit. [provided by Alliance of Genome Resources, Apr 2022]