Structure via PubChem · Public domain (PubChem)
fenproporex
Sign in to saveAlso known as Perphoxene, Fenorex
Fenproporex (Perphoxene) (N-2-Cyanoethylamphetamine) (3-(1-phenylpropan-2-ylamino)propanenitrile) (3-[(1-Methyl-2-Phenylethyl)amino]propiononitrile) is a stimulant drug of the phenethylamine and amphetamine chemical classes that was developed in the 1960s. It is used as an appetite suppressant for the treatment of obesity.
Chemical data
- Formula
- C12H16N2
- Molecular weight
- 188.27 g/mol
- IUPAC name
- 3-(1-phenylpropan-2-ylamino)propanenitrile
- SMILES
- CC(CC1=CC=CC=C1)NCCC#N
- InChIKey
- IQUFSXIQAFPIMR-UHFFFAOYSA-N
- XLogP
- 1.9
- Polar surface area
- 35.8 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
80 papers- Safety and efficacy of fenproporex for obesity treatment: a systematic review.Revista de saude publica · 2016
- Acute administration of fenproporex increased acetylcholinesterase activity in brain of young rats.Anais da Academia Brasileira de Ciencias · 2015
- Behavioral neurotoxicity in adolescent and adult mice exposed to fenproporex during pregnancy.Human & experimental toxicology · 2005
- Amphetamine and fenproporex levels following multidose administration of fenproporex.Journal of analytical toxicology · 1999
- Fenproporex increases locomotor activity and alters energy metabolism, and mood stabilizers reverse these changes: a proposal for a new animal model of mania.Molecular neurobiology · 2014
via PubMed
Wikidata facts
- Mass
- 188.131349
- Has use
- medication
Show 3 more facts
- chemical formula
- C₁₂H₁₆N₂
- canonical SMILES
- CC(CC1=CC=CC=C1)NCCC#N
- MCN code
- 3003.90.54
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Fenproporex (Perphoxene) (N-2-Cyanoethylamphetamine) (3-(1-phenylpropan-2-ylamino)propanenitrile) (3-[(1-Methyl-2-Phenylethyl)amino]propiononitrile) is a stimulant drug of the phenethylamine and amphetamine chemical classes that was developed in the 1960s. It is used as an appetite suppressant for the treatment of obesity.
Fenproporex produces amphetamine as a metabolite and was withdrawn in many countries following problems with abuse, but it is still prescribed in some countries. It is sometimes combined with benzodiazepines, antidepressants, and other compounds to create a version of the "rainbow diet pill".
Excerpted from Wikipedia’s “fenproporex” article, available under the CC BY-SA 4.0 licence.