Structure via PubChem · Public domain (PubChem)
fexofenadine
Sign in to saveAlso known as 4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl}-alpha,alpha-dimethylbenzeneacetic acid, terfenadine-COOH, terfenadine carboxylate, terfenadine acid metabolite, carboxyterfenadine
Fexofenadine, sold under the brand name Allegra among others, is an antihistamine medication used in the treatment of allergy symptoms such as allergic rhinitis and urticaria.
Key facts
- Drug.PubChem
- 3348
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 459589155
- Drug.image
- Fexofenadine2DCSD.svg
- Drug.image_class
- skin-invert-image
- Drug.alt
- Skeletal formula of fexofenadine
- Drug.width
- 260
- Drug.chirality
- Racemic mixture
- Drug.image2
- Fexofenadine 3D ball.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Ball-and-stick model of fexofenadine
- Drug.tradename
- Allegra, others
- Drug.MedlinePlus
- a697035
- Drug.DailyMedID
- Fexofenadine
- Drug.pregnancy_AU
- B2
- Drug.routes_of_administration
- By mouth
- Drug.class
- Antihistamine; H1 receptor antagonist
via Wikipedia infobox
Chemical data
- Formula
- C32H39NO4
- Molecular weight
- 501.7 g/mol
- IUPAC name
- 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid
- SMILES
- CC(C)(C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O)C(=O)O
- InChIKey
- RWTNPBWLLIMQHL-UHFFFAOYSA-N
- XLogP
- 3
- Polar surface area
- 81 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
1,212 papers- Fexofenadine.Drugs · 1998
- Why fexofenadine is considered as a truly non-sedating antihistamine with no brain penetration: a systematic review.Current medical research and opinion · 2024
- Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review.Clinical pharmacokinetics · 2008
- Fexofenadine hydrochloride--a new anti-histaminic drug.The Israel Medical Association journal : IMAJ · 2001
- An update on the clinical pharmacokinetics of fexofenadine enantiomers.Expert opinion on drug metabolism & toxicology · 2018
via PubMed
~8 min read
Encyclopedic overview
12 sectionsContents
- Medical uses
- Efficacy
- Side effects
- Overdose
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Interactions
- History
- Society and culture
- Brand names
- References
Fexofenadine, sold under the brand name Allegra among others, is an antihistamine medication used in the treatment of allergy symptoms such as allergic rhinitis and urticaria.
Therapeutically, fexofenadine is a selective peripheral H1 blocker. It is classified as a second-generation antihistamine because it is less able to pass the blood–brain barrier and cause sedation, compared to first-generation antihistamines.
Excerpted from Wikipedia’s “fexofenadine” article, available under the CC BY-SA 4.0 licence.