FEZ1
Sign in to saveAlso known as UNC-76, fasciculation and elongation protein zeta 1
Fasciculation and elongation protein zeta-1 is a protein that in humans is encoded by the FEZ1 gene.
Gene data
FEZ1- Name
- fasciculation and elongation protein zeta 1
- Type
- protein-coding
- Aliases
- UNC-76
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
fasciculation and elongation protein zeta 1
- Symbol
- FEZ1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:125,442,881-125,592,578
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 21063
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9638
- genomic end
- 125592568
- genomic start
- 125442881
- chromosome
- human chromosome 11
- cytogenetic location
- 11q24.2
- expressed in
- substantia nigra
Sources (4)
via Wikidata · CC0
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Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Fasciculation and elongation protein zeta-1 is a protein that in humans is encoded by the FEZ1 gene.
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.
Excerpted from Wikipedia’s “FEZ1” article, available under the CC BY-SA 4.0 licence.