PAM16
Sign in to saveAlso known as MAGMAS, TIM16, TIMM16, CGI-136, SMDMDM, presequence translocase-associated motor 16 homolog (S. cerevisiae), presequence translocase associated motor 16 homolog, presequence translocase associated motor 16
Mitochondrial import inner membrane translocase subunit TIM16 also known as presequence translocated-associated motor subunit PAM16, mitochondria-associated granulocyte macrophage CSF-signaling molecule, or presequence translocated-associated motor subunit PAM16 is a protein that in humans is encoded by the PAM16 gene.
Gene data
PAM16- Name
- presequence translocase associated motor 16
- Type
- protein-coding
- Aliases
- CGI-136, MAGMAS, SMDMDM, TIM16, TIMM16
This gene encodes a mitochondrial protein involved in granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling. This protein also plays a role in the import of nuclear-encoded mitochondrial proteins into the mitochondrial matrix and may be important in reactive oxygen species (ROS) homeostasis. Mutations in this gene cause Megarbane-Dagher-Melike type spondylometaphyseal dysplasia, an early lethal skeletal dysplasia characterized by short stature, developmental delay and other skeletal abnormalities. [provided by RefSeq, May 2017].
via MyGene.info
Gene · Ensembl
presequence translocase associated motor 16
- Symbol
- PAM16
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:4,330,378-4,355,607
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 41100
- exact match
- identifiers.org/ncbigene/51025
- genomic start
- 4381550
- genomic end
- 4405608
- cytogenetic location
- 16p13.3
Sources (4)
via Wikidata · CC0
~2 min read
Article
6 sectionsContents
- Structure
- Function
- Clinical Significance
- Interactions
- References
- Further reading
Mitochondrial import inner membrane translocase subunit TIM16 also known as presequence translocated-associated motor subunit PAM16, mitochondria-associated granulocyte macrophage CSF-signaling molecule, or presequence translocated-associated motor subunit PAM16 is a protein that in humans is encoded by the PAM16 gene.
== Structure == The PAM16 gene is located on the p arm of chromosome 16 at position 13.3 and it spans 11,150 base pairs. The PAM16 gene produces a 15.1 kDa protein composed of 137 amino acids. The structure has been found to contain a 21-residue mitochondrial targeting leader sequence.