filamins
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Filamins are a class of proteins that hold two actin filaments at large angles. Filamin protein in mammals is made up of an actin-binding domain at its N-terminus that is followed by 24 immunoglobulin-like repeat modules of roughly 95 amino acids. There are two hinge regions; between repeats 15-16 and 23-24. Filamin gets cleaved at these hinge regions to generate smaller fragments of the protein. Filamin has two actin-binding sites with a V-linkage between them, so that it cross-links actin filaments into a network with the filaments orientated almost at right angles to one another.
Research
2,630 papers- The filamins of Drosophila.Genome · 2025
- Filamins in cardiovascular development.Trends in cardiovascular medicine · 2007
- Filamins: promiscuous organizers of the cytoskeleton.Trends in biochemical sciences · 2006
- The filamins: properties and functions.Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire · 1985
- Filamins in cell signaling, transcription and organ development.Trends in cell biology · 2010
via PubMed
~3 min read
Article
4 sectionsContents
- FLNA
- FLNC
- References
- External links
Filamins are a class of proteins that hold two actin filaments at large angles. Filamin protein in mammals is made up of an actin-binding domain at its N-terminus that is followed by 24 immunoglobulin-like repeat modules of roughly 95 amino acids. There are two hinge regions; between repeats 15-16 and 23-24. Filamin gets cleaved at these hinge regions to generate smaller fragments of the protein. Filamin has two actin-binding sites with a V-linkage between them, so that it cross-links actin filaments into a network with the filaments orientated almost at right angles to one another.
Filamin proteins include: FLNA FLNB FLNC