flesinoxan
Sign in to saveAlso known as (+)-flesinoxan, DU-29,373
Flesinoxan (DU-29,373) is a potent and selective 5-HT1A receptor partial/near-full agonist of the phenylpiperazine class. Originally developed as a potential antihypertensive drug, flesinoxan was later found to possess antidepressant and anxiolytic effects in animal tests. As a result, it was investigated in several small human pilot studies for the treatment of major depressive disorder, and was found to have robust effectiveness and very good tolerability. However, due to "management decisions", the development of flesinoxan was stopped and it was not pursued any further.
Research
261 papers- Serotonin control of sleep-wake behavior.Sleep medicine reviews · 2011
- Flesinoxan, a 5-HT1A receptor agonist/alpha 1-adrenoceptor antagonist, lowers intraocular pressure in NZW rabbits.Current eye research · 2001
- Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study.Neuropharmacology · 1995
- Two-lever drug-drug discrimination with the 5-HT1 receptor agonists flesinoxan and eltoprazine.The international journal of neuropsychopharmacology · 2000
- Hormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2004
via PubMed
~2 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- External links
{{Drugbox | IUPAC_name = 4-fluoro-N-(2-{4-[(2S)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-5-yl]piperazin-1-yl}ethyl)benzamide | image = Flesinoxan.svg | image_class = skin-invert-image
| tradename = | pregnancy_category = | legal_status = Uncontrolled | routes_of_administration = Oral
Excerpted from Wikipedia’s “flesinoxan” article, available under the CC BY-SA 4.0 licence.