GCHFR
Sign in to saveAlso known as GFRP, HsT16933, P35, GTP cyclohydrolase I feedback regulator
GTP cyclohydrolase 1 feedback regulatory protein is an enzyme that in humans is encoded by the GCHFR gene.
In the Vinony graph
Vinony's link graph records 2 inbound references to GCHFR, and connects out to PubMed, human chromosome 15 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 15.
Vinony links it to 8 Wikipedia language editions.
Gene data
GCHFR- Name
- GTP cyclohydrolase I feedback regulator
- Type
- protein-coding
- Position
- 40,764,043–40,767,872 (+)
- Aliases
- GFRP, HsT16933, P35
- Ensembl
- ENSG00000137880
- RefSeq RNA
- NM_005258.3
- RefSeq protein
- NP_005249.1
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
GTP cyclohydrolase I feedback regulator
- Symbol
- GCHFR
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:40,764,043-40,767,872
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein GCHFR PDB 1is7.png
Show 7 more facts
- HomoloGene ID
- 3849
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2644
- genomic end
- 40767708
- genomic start
- 40764068
- chromosome
- human chromosome 15
- cytogenetic location
- 15q15.1
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
GTP cyclohydrolase 1 feedback regulatory protein is an enzyme that in humans is encoded by the GCHFR gene.
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.
Excerpted from Wikipedia’s “GCHFR” article, available under the CC BY-SA 4.0 licence.