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GeneQ18032826· pop 5· linked from 4 articles

GFI1B

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Also known as BDPLT17, ZNF163B, growth factor independent 1B transcriptional repressor

Zinc finger protein Gfi-1b is a protein that in humans is encoded by the GFI1B gene.

In the Vinony graph

Vinony's link graph records 4 inbound references to GFI1B, and connects out to Q180686, human chromosome 9 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 9.

Vinony links it to 5 Wikipedia language editions.

Gene data

GFI1B

Name: growth factor independent 1B transcriptional repressor
Type: protein-coding
Position: 132,944,000–132,991,687 (+)
Aliases: BDPLT17, ZNF163B
Ensembl: ENSG00000165702
RefSeq RNA: NM_001135031.2, NM_001371908.1, NM_001377304.1, NM_001377305.1, NM_004188.8
RefSeq protein: NP_001128503.1, NP_001358837.1, NP_001364233.1, NP_001364234.1, NP_004179.3

This gene encodes a zinc-finger containing transcriptional regulator that is primarily expressed in cells of hematopoietic lineage. The encoded protein complexes with numerous other transcriptional regulatory proteins including GATA-1, runt-related transcription factor 1 and histone deacetylases to control expression of genes involved in the development and maturation of erythrocytes and megakaryocytes. Mutations in this gene are the cause of the autosomal dominant platelet disorder, platelet-type bleeding disorder-17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of hemopoiesis negative regulation of G1/S transition of mitotic cell cycle

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific protein binding RNA polymerase II-specific DNA-binding transcription factor binding sequence-specific double-stranded DNA binding

Cellular component

nucleus nucleus nucleus nucleoplasm transcription regulator complex transcription regulator complex nuclear matrix nuclear matrix

via MyGene.info

Gene · Ensembl

growth factor independent 1B transcriptional repressor

Symbol: GFI1B
Biotype: Protein coding
Organism: Homo sapiens
Location: 9:132,944,000-132,991,687
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 31223
exact match: identifiers.org/ncbigene/8328
genomic end: 135867083
genomic start: 135820932
cytogenetic location: 9q34.13

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Zinc finger protein Gfi-1b is a protein that in humans is encoded by the GFI1B gene.

==References==

Excerpted from Wikipedia’s “GFI1B” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 9