HDAC7

Name

histone deacetylase 7

Type

protein-coding

Position

47,782,722–47,833,132 (−)

Aliases

HD7, HD7A, HDAC7A

Ensembl

ENSG00000061273

RefSeq RNA

NM_001098416.4, NM_001308090.2, NM_001368046.1, NM_015401.5, NM_016596.3

RefSeq protein

NP_001091886.1, NP_001295019.1, NP_001354975.1, NP_056216.2, XP_011536782.1

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

histone deacetylase 7

Symbol

HDAC7

Biotype

Protein coding

Organism

Homo sapiens

Location

12:47,782,722-47,833,132

Strand

Reverse (−)

Assembly

GRCh38

• HDAC7: a promising target in cancer.Frontiers in oncology · 2024
• Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis.Molecular neurodegeneration · 2025
• HDAC7 drives glioblastoma to a mesenchymal-like state via LGALS3-mediated crosstalk between cancer cells and macrophages.Theranostics · 2024
• HDAC7 promotes renal cancer progression by reprogramming branched-chain amino acid metabolism.Science advances · 2025
• HDAC7 is a potential therapeutic target in acute erythroid leukemia.Leukemia · 2024

via PubMed

Wikidata facts

Image

Protein HDAC7A PDB 2nvr.png

via Wikidata · CC0