EDNRA

Also known as ET-A, ETA, ETA-R, ETAR, ETRA, hET-AR, MFDA, endothelin receptor type A

protein-coding gene in the species Homo sapiens

Gene data

EDNRA

Name: endothelin receptor type A
Type: protein-coding
Position: 147,480,917–147,544,954 (+)
Aliases: ET-A, ETA, ETA-R, ETAR, ETRA, MFDA, hET-AR
Ensembl: ENSG00000151617
RefSeq RNA: NM_001166055.2, NM_001256283.1, NM_001354797.2, NM_001957.4, NR_045958.2
RefSeq protein: NP_001159527.1, NP_001341726.1, NP_001948.1

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].