homosalate
Sign in to saveHomosalate is an organic compound used in some sunscreens. It is made by the Fischer–Speier esterification of salicylic acid and 3,3,5-trimethylcyclohexanol, the latter being a hydrogenated derivative of isophorone. Contained in 45% of U.S. sunscreens, it is used as a chemical UV filter. The salicylic acid portion of the molecule absorbs ultraviolet rays with a wavelength from 295 nm to 315 nm, protecting the skin from sun damage. The hydrophobic trimethyl cyclohexyl group provides greasiness that prevents it from dissolving in water.
Research
166 papers- Homosalate boosts the release of tumour-derived extracellular vesicles with protection against anchorage-loss property.Journal of extracellular vesicles · 2022
- Homosalate and ERK Knockdown in the Modulation of Aurelia coerulea Metamorphosis by Regulating the PI3K Pathway and ERK Pathway.Current issues in molecular biology · 2024
- Sunscreens.2006
- Toxicokinetics of homosalate in humans after dermal application: applicability of oral-route data for exposure assessment by human biomonitoring.Archives of toxicology · 2024
- Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial.JAMA · 2020
via PubMed
Wikidata facts
- Mass
- 262.157
Show 3 more facts
- chemical formula
- C₁₆H₂₂O₃
- canonical SMILES
- CC1CC(CC(C1)(C)C)OC(=O)C2=CC=CC=C2O
- Commons category
- Homosalate
Sources (2)
via Wikidata · CC0
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Article
2 sectionsContents
- Safety
- References
Homosalate is an organic compound used in some sunscreens. It is made by the Fischer–Speier esterification of salicylic acid and 3,3,5-trimethylcyclohexanol, the latter being a hydrogenated derivative of isophorone. Contained in 45% of U.S. sunscreens, it is used as a chemical UV filter. The salicylic acid portion of the molecule absorbs ultraviolet rays with a wavelength from 295 nm to 315 nm, protecting the skin from sun damage. The hydrophobic trimethyl cyclohexyl group provides greasiness that prevents it from dissolving in water.
==Safety== Homosalate was identified in a court case brought by German chemical company Symrise who claimed that the ingredient used in sunscreen did not require animal testing.