HPGDS

Also known as GSTS, GSTS1-1, PGD2, PGDS, GSTS1, hematopoietic prostaglandin D synthase

(Hematopoietic) PGDS protein, also known as Glutathione-Dependent PGD Synthase, is a protein that in humans is encoded by the HPGDS gene.

Gene data

HPGDS

Name: hematopoietic prostaglandin D synthase
Type: protein-coding
Position: 94,298,507–94,342,876 (−)
Aliases: GSTS, GSTS1, GSTS1-1, PGD2, PGDS
Ensembl: ENSG00000163106
RefSeq RNA: NM_014485.3, XM_005262932.4, XM_054349696.1
RefSeq protein: NP_055300.1, XP_005262989.1, XP_054205671.1

Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

prostaglandin metabolic process prostaglandin metabolic process glutathione metabolic process signal transduction locomotory behavior cyclooxygenase pathway

Molecular function

magnesium ion binding glutathione transferase activity glutathione transferase activity prostaglandin-D synthase activity prostaglandin-D synthase activity prostaglandin-D synthase activity calcium ion binding protein binding

Cellular component

cytoplasm cytoplasm cytosol cytosol

Pathways

Glutathione metabolism - Homo sapiens (human)Arachidonic acid metabolism - Homo sapiens (human)Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)Drug metabolism - cytochrome P450 - Homo sapiens (human)Chemical carcinogenesis - Homo sapiens (human)Metabolism Phase II - Conjugation of compounds Glutathione conjugation Biological oxidations Arachidonate metabolism

via MyGene.info

Gene · Ensembl

hematopoietic prostaglandin D synthase

Symbol: HPGDS
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:94,298,507-94,342,876
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein PGDS PDB 1iyh.png

Show 5 more facts

HomoloGene ID: 113741
exact match: identifiers.org/ncbigene/27306
genomic end: 95264027
genomic start: 95219686
cytogenetic location: 4q22.3

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Further reading

(Hematopoietic) PGDS protein, also known as Glutathione-Dependent PGD Synthase, is a protein that in humans is encoded by the HPGDS gene.

Gluthionine-dependent Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. As a type of Prostaglandin-D synthase, it catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes.