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GeneQ18040063· pop 5· linked from 3 articles

HSD17B11

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Also known as 17-BETA-HSD11, 17-BETA-HSDXI, 17BHSD11, DHRS8, PAN1B, RETSDR2, SDR16C2, hydroxysteroid (17-beta) dehydrogenase 11

Estradiol 17-beta-dehydrogenase 11 is an enzyme that in humans is encoded by the HSD17B11 gene.

In the Vinony graph

Vinony's link graph records 3 inbound references to HSD17B11, and connects out to PubMed, human chromosome 4 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 4.

Vinony links it to 4 Wikipedia language editions.

Gene data

HSD17B11

Name: hydroxysteroid 17-beta dehydrogenase 11
Type: protein-coding
Position: 87,336,162–87,391,223 (−)
Aliases: 17-BETA-HSD11, 17-BETA-HSDXI, 17BHSD11, DHRS8, PAN1B, RETSDR2, SDR16C2
Ensembl: ENSG00000198189
RefSeq RNA: NM_016245.5, XM_011532021.2, XM_054350152.1
RefSeq protein: NP_057329.3, XP_011530323.1, XP_054206127.1

Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009].

Gene Ontology

Biological process

estrogen biosynthetic process androgen catabolic process

Molecular function

estradiol 17-beta-dehydrogenase [NAD(P)+] activity estradiol 17-beta-dehydrogenase [NAD(P)+] activity estradiol 17-beta-dehydrogenase [NAD(P)+] activity protein binding steroid dehydrogenase activity steroid dehydrogenase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Cellular component

cytoplasm endoplasmic reticulum endoplasmic reticulum lipid droplet lipid droplet lipid droplet lipid droplet cytosol

Pathways

Metabolism Estrogen biosynthesis Metabolism of steroid hormones Metabolism of lipids Metabolism of steroids

via MyGene.info

Gene · Ensembl

hydroxysteroid 17-beta dehydrogenase 11

Symbol: HSD17B11
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:87,336,162-87,391,223
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein HSD17B11 PDB 1yb1.png

Show 9 more facts

HomoloGene ID: 69209
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/51170
genomic start: 87336515
chromosome: human chromosome 4
genomic end: 87391188
cytogenetic location: 4q22.1
expressed in: blood
Commons category: HSD17B11

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Estradiol 17-beta-dehydrogenase 11 is an enzyme that in humans is encoded by the HSD17B11 gene.

HSD17B11 expression has been linked to higher survival rates for lung cancer patients.

Excerpted from Wikipedia’s “HSD17B11” article, available under the CC BY-SA 4.0 licence.

Available in 4 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 4