ibutilide

Also known as Corvert®, U-70226E, N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide, Ibutilidum, Ibutilid, Ibutilida

Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells. Because of its Class III antiarrhythmic activity, there should not be concomitant administration of Class Ia and Class III agents.

Chemical data

Formula: C20H36N2O3S
Molecular weight: 384.6 g/mol
IUPAC name: N-[4-[4-[ethyl(heptyl)amino]-1-hydroxybutyl]phenyl]methanesulfonamide

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1995
Admin. routes: parenteral
Indications: cardiac arrhythmia

via ChEMBL · EBI

Research

422 papers

Ibutilide.Circulation · 1998
Ibutilide.2026
Ibutilide: what's clinically proven, what's being investigated?Indian pacing and electrophysiology journal · 2026
Ibutilide: an antiarrhythmic agent for the treatment of atrial fibrillation or flutter.The Annals of pharmacotherapy · 1999
Ibutilide: a new class III antiarrhythmic agent.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 1998

via PubMed

Wikidata facts

Mass: 384.244664

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chemical formula: C₂₀H₃₆N₂O₃S
canonical SMILES: CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O
defined daily dose: 1

Sources (4)

via Wikidata · CC0

~5 min read

Article

10 sections

Contents

Mechanism of action
Pharmacokinetics
Absorption
Distribution
Metabolism
Excretion
Adverse effects and contraindications
Patient Information
See also
References

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