icatibant
Sign in to saveAlso known as HOE-140, HOE 140
Icatibant, sold under the brand name Firazyr, is a medication for the symptomatic treatment of acute attacks of hereditary angioedema (HAE) in adults with C1-esterase-inhibitor deficiency. It is not effective in angioedema caused by medication from the ACE inhibitor class.
Research
1,542 papers- Is Icatibant Safe for the Treatment of Hereditary Angioedema During Pregnancy?Current allergy and asthma reports · 2022
- Icatibant for hereditary angioedema.Drugs of today (Barcelona, Spain : 1998) · 2009
- Icatibant in viral infections.Infectious diseases (London, England) · 2023
- The Icatibant Outcome Survey: 10 years of experience with icatibant for patients with hereditary angioedema.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
- Icatibant for the treatment of hereditary angioedema.The Annals of pharmacotherapy · 2013
via PubMed
Wikidata facts
- Mass
- 1303.661
Show 5 more facts
- chemical formula
- C₅₉H₈₉N₁₉O₁₃S
- World Health Organisation international non-proprietary name
- icatibant
- isomeric SMILES
- C1CC[C@H]2[C@@H](C1)C[C@H](N2C(=O)[C@H]3CC4=CC=CC=C4CN3C(=O)[C@H](CO)NC(=O)[C@H](CC5=CC=CS5)NC(=O)CNC(=O)[C@@H]6C[C@H](CN6C(=O)[C@@H]7CCCN7C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)N)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O
- canonical SMILES
- C1CCC2C(C1)CC(N2C(=O)C3CC4=CC=CC=C4CN3C(=O)C(CO)NC(=O)C(CC5=CC=CS5)NC(=O)CNC(=O)C6CC(CN6C(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)N)O)C(=O)NC(CCCN=C(N)N)C(=O)O
- defined daily dose
- 30
Sources (3)
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Article
4 sectionsContents
- Mechanism of action
- Society and culture
- Legal status
- References
Icatibant, sold under the brand name Firazyr, is a medication for the symptomatic treatment of acute attacks of hereditary angioedema (HAE) in adults with C1-esterase-inhibitor deficiency. It is not effective in angioedema caused by medication from the ACE inhibitor class.
It is a peptidomimetic consisting of ten amino acids, which is a selective and specific antagonist of bradykinin B2 receptors.
Connections
Serpin family G member 1
Protein
Jerini
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amino acid
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Q180686
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ACE inhibitor
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IUPAC nomenclature of chemistry
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Categories
Anti-inflammatory agentsChemicals using indexlabelsDrugboxes which contain changes to verified fieldsDrugboxes which contain changes to watched fieldsDrugs developed by Takeda Pharmaceutical CompanyDrugs with non-standard legal statusMultiple chemicals in Infobox drugOrphan drugsPeptide therapeutics