indorenate
Sign in to saveIndorenate (TR-3369), is a tryptamine derivative which acts as an agonist at the 5-HT1A, 5-HT1B and 5-HT2C serotonin receptors. It has anxiolytic, antihypertensive and anorectic effects, predominantly through action at 5-HT1A, but with some contribution from the 5-HT1B and 5-HT2C subtypes, and possibly some other non-serotonergic targets also.
Research
59 papers- Indorenate modifies a1-adrenergic and benzodiazepine receptor binding in the rat brain: an autoradiography study.The Journal of pharmacy and pharmacology · 2006
- Indorenate produces antidepressant-like actions in the rat forced swimming test via 5-HT1A receptors.Psychopharmacology · 2002
- Indorenate improves motor function in rats with chronic spinal cord injury.Basic & clinical pharmacology & toxicology · 2007
- Discriminative stimulus properties of indorenate, a serotonin agonist.Journal of psychiatry & neuroscience : JPN · 1999
- New hypoglycemic effects of indorenate mediated by the 5-HT1a and 5-HT2a receptors: in vivo and in silico studies.Canadian journal of physiology and pharmacology · 2026
via PubMed
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Encyclopedic overview
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Indorenate (TR-3369), is a tryptamine derivative which acts as an agonist at the 5-HT1A, 5-HT1B and 5-HT2C serotonin receptors. It has anxiolytic, antihypertensive and anorectic effects, predominantly through action at 5-HT1A, but with some contribution from the 5-HT1B and 5-HT2C subtypes, and possibly some other non-serotonergic targets also.
== See also == 5-Methoxytryptamine Acetryptine
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