Interleukin 6

Protein · UniProt

Interleukin-6

Gene

IL6

Organism

Homo sapiens (Human)

Length

212 aa

Molecular mass

23,718 Da

Evidence

1: Evidence at protein level

Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable)

• NACOMPLETED
  A Study to Evaluate the Ability of TNFR:Fc to Decrease the Amount of IL-6 (Interleukin-6) and TNF-alpha (Tumor Necrosis Factor) in HIV-Infected PatientsNational Institute of Allergy and Infectious Diseases (NIAID) · NCT00001116
• PHASE2ACTIVE_NOT_RECRUITING
  A Phase II Study of the Interleukin-6 Receptor Inhibitor Tocilizumab in Combination With Ipilimumab and Nivolumab in Patients With Unresectable Stage III or Stage IV MelanomaNYU Langone Health · NCT03999749
• COMPLETED
  Tocilizumab Effect on microRNA Expression and Adipokine Levels in Rheumatoid Arthritis PatientsCarmel Medical Center · NCT03149796
• NACOMPLETED
  Whole Body Vibration Versus Aerobic Training on Interleukin 6 and Endurance After Renal TransplantationCairo University · NCT07333105
• PHASE1/PHASE2COMPLETED
  Feasibility of the Combination of Chemotherapy (Carbo/Caelyx or Carbo/Doxorubicin) With Tocilizumab (mAb IL-6R) and Peg-Intron in Patients With Recurrent Ovarian CancerLeiden University Medical Center · NCT01637532
• NACOMPLETED
  Inflammatory Stress Response in Pediatric Inguinal Hernia RepairUniversity Hospital of Split · NCT03203343

via ClinicalTrials.gov

Wikidata facts

via Wikidata · CC0