Structure via PubChem · Public domain (PubChem)
iotrolan
Sign in to saveAlso known as Iotrolum, Iotrolanum
Iotrolan (trade name Isovist) is an iodine-containing radiocontrast agent, a substance used to improve the visibility of body structures on images obtained by X-ray techniques.
In the Vinony graph
Within Vinony's link graph, iotrolan is referenced by 61 other articles, and connects out to radiocontrast agent, microparticle and MRI contrast agent.
It is catalogued under topics including Anilides, Benzamides and Chemical pages without DrugBank identifier.
Its subject is documented across 5 Wikipedia language editions.
Chemical data
- Formula
- C37H48I6N6O18
- Molecular weight
- 1626.2 g/mol
- IUPAC name
- 2,4,6-triiodo-5-[methyl-[3-oxo-3-[2,4,6-triiodo-N-methyl-3,5-bis(1,3,4-trihydroxybutan-2-ylcarbamoyl)anilino]propanoyl]amino]-1-N,3-N-bis(1,3,4-trihydroxybutan-2-yl)benzene-1,3-dicarboxamide
- SMILES
- CN(C1=C(C(=C(C(=C1I)C(=O)NC(CO)C(CO)O)I)C(=O)NC(CO)C(CO)O)I)C(=O)CC(=O)N(C)C2=C(C(=C(C(=C2I)C(=O)NC(CO)C(CO)O)I)C(=O)NC(CO)C(CO)O)I
- InChIKey
- XUHXFSYUBXNTHU-UHFFFAOYSA-N
- XLogP
- -4.2
- Polar surface area
- 400 Ų
- H-bond donors
- 16
- H-bond acceptors
- 18
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Unknown
- First approval
- 1989
- Admin. routes
- parenteral
via ChEMBL · EBI
Research
289 papers- [The new nonionic contrast preparation for myelography iotrolan].Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko · 1994
- Iotrolan versus iopamidol: a controlled, multicenter, double-blind study of lumbar and direct cervical myelography.Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband · 1989
- The lack of immunogenicity of iotrolan.Investigative radiology · 1995
- Safety and pharmacokinetics of iotrolan in hysterosalpingography. Retention and irritability compared with Lipiodol.Investigative radiology · 1995
- Aseptic meningitis complicating iotrolan myelography.AJNR. American journal of neuroradiology · 1991
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 1625.729
Show 3 more facts
- chemical formula
- C₃₇H₄₈I₆N₆O₁₈
- canonical SMILES
- CN(C1=C(C(=C(C(=C1I)C(=O)NC(CO)C(CO)O)I)C(=O)NC(CO)C(CO)O)I)C(=O)CC(=O)N(C)C2=C(C(=C(C(=C2I)C(=O)NC(CO)C(CO)O)I)C(=O)NC(CO)C(CO)O)I
- subject has role
- contrast agent
Sources (2)
via Wikidata · CC0
~4 min read
Encyclopedic overview
6 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Interactions
- Chemistry and mechanism of action
- References
{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 407439119 | IUPAC_name = 2,4,6-triiodo-5-{N-methyl-2-[methyl({2,4,6-triiodo-3,5-bis[(1,3,4-trihydroxybutan-2-yl)carbamoyl]phenyl})carbamoyl]acetamido}-1-N,3-N-bis(1,3,4-trihydroxybutan-2-yl)benzene-1,3-dicarboxamide | image = Iotrolan.png | image_class = skin-invert-image | width = 300
| tradename = Isovist | Drugs.com = | pregnancy_AU = | pregnancy_US = | pregnancy_category = Contraindicated | legal_AU = | legal_UK = | legal_US = | legal_status = Rx-only | routes_of_administration =
Excerpted from Wikipedia’s “iotrolan” article, available under the CC BY-SA 4.0 licence.