iprindole
Sign in to saveAlso known as pramindole, 3-(6,7,8,9,10,11-hexahydro- 5H-cycloocta[b]indol-5-yl)-N,N-dimethylpropan-1-amine, Prondol, Galatur, Tertran
Iprindole, sold under the brand names Prondol, Galatur, and Tertran, is an atypical tricyclic antidepressant (TCA) that has been used in the United Kingdom and Ireland for the treatment of depression but appears to no longer be marketed. It was developed by Wyeth and was marketed in 1967. The drug has been described by some as the first "second-generation" antidepressant to be introduced. However, it was very little-used compared to other TCAs, with the number of prescriptions dispensed only in the thousands.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 439569389
- Drug.IUPAC_name
- 3-(6,7,8,9,10,11-hexahydro-5H-cycloocta[b]indol-5-yl)-N,N-dimethylpropan-1-amine
- Drug.image
- Iprindole.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200px
- Drug.image2
- Iprindole molecule ball.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 200px
- Drug.tradename
- Prondol, Galatur, Tertran
- Drug.legal_status
- Rx-only
- Drug.routes_of_administration
- Oral
- Drug.metabolism
- Hepatic
- Drug.elimination_half life
- 52.5 hours
- Drug.excretion
- Urine, Feces
- Drug.CAS_number
- 5560-72-5
- Drug.CAS_supplemental
- 20432-64-8 (hydrochloride)
- Drug.ATC_prefix
- N06
via Wikipedia infobox
Research
319 papers- Metabolism of some "second"- and "fourth"-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine.Cellular and molecular neurobiology · 1999
- Antidepressant overdosage.Drugs · 1982
- Iprindole: a cornerstone in the neurobiological investigation of antidepressant treatments.Modern problems of pharmacopsychiatry · 1982
- The effects of iprindole on noradrenergic transmission in the rat anococcygeus muscle.Naunyn-Schmiedeberg's archives of pharmacology · 1983
- Effects of neonatally administered iprindole on adult behaviors of rats.Pharmacology, biochemistry, and behavior · 1996
via PubMed
Wikidata facts
- Mass
- 284.225
Show 4 more facts
- chemical formula
- C₁₉H₂₈N₂
- defined daily dose
- 90
- canonical SMILES
- CN(C)CCCN1C2=C(CCCCCC2)C3=CC=CC=C31
- Commons category
- Iprindole
Sources (3)
via Wikidata · CC0
~7 min read
Article
16 sectionsContents
- Medical uses
- Contraindications
- Side effects
- Overdose
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- Society and culture
- Generic names
- Brand names
- Availability
- References
- Further reading
Iprindole, sold under the brand names Prondol, Galatur, and Tertran, is an atypical tricyclic antidepressant (TCA) that has been used in the United Kingdom and Ireland for the treatment of depression but appears to no longer be marketed. It was developed by Wyeth and was marketed in 1967. The drug has been described by some as the first "second-generation" antidepressant to be introduced. However, it was very little-used compared to other TCAs, with the number of prescriptions dispensed only in the thousands.
==Medical uses== Iprindole was used in the treatment of major depressive disorder in dosages similar to those of other TCAs.