ITGB3BP
Sign in to saveAlso known as CENP-R, CENPR, HSU37139, NRIF3, TAP20, integrin subunit beta 3 binding protein
Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene.
Gene data
ITGB3BP- Name
- integrin subunit beta 3 binding protein
- Type
- protein-coding
- Position
- 63,320,884–63,593,721 (−)
- Aliases
- CENP-R, CENPR, HSU37139, NRIF3, TAP20
- Ensembl
- ENSG00000142856
- RefSeq RNA
- NM_001206739.2, NM_001347145.2, NM_001347147.2, NM_001347148.2, NM_014288.5
- RefSeq protein
- NP_001193668.1, NP_001334074.1, NP_001334076.1, NP_001334077.1, NP_055103.3
This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
integrin subunit beta 3 binding protein
- Symbol
- ITGB3BP
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:63,320,884-63,593,721
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene.
==Interactions== ITGB3BP has been shown to interact with: CD61, Cyclin A2, NFKB1, RXRA, RXRG, and THRA.
Excerpted from Wikipedia’s “ITGB3BP” article, available under the CC BY-SA 4.0 licence.
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