THRA
Sign in to saveAlso known as AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1
protein-coding gene in the species Homo sapiens
Gene data
THRA- Name
- thyroid hormone receptor alpha
- Type
- protein-coding
- Position
- 40,058,290–40,093,867 (+)
- Aliases
- AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, THRalpha
- Ensembl
- ENSG00000126351
- RefSeq RNA
- NM_001190918.2, NM_001190919.2, NM_003250.6, NM_199334.5, XM_047436632.1
- RefSeq protein
- NP_001177847.1, NP_001177848.1, NP_003241.2, NP_955366.1, XP_047292588.1
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
negative regulation of transcription by RNA polymerase IIthyroid hormone receptor signaling pathwaypositive regulation of thyroid hormone receptor signaling pathwaypositive regulation of thyroid hormone receptor signaling pathwayregulation of DNA-templated transcriptionregulation of transcription by RNA polymerase IItranscription by RNA polymerase IIhormone-mediated signaling pathway
Molecular function
transcription cis-regulatory region bindingtranscription cis-regulatory region bindingRNA polymerase II cis-regulatory region sequence-specific DNA bindingDNA-binding transcription factor activity, RNA polymerase II-specificDNA-binding transcription factor activity, RNA polymerase II-specificDNA bindingDNA-binding transcription factor activityDNA-binding transcription factor activity
Cellular component
Pathways
Neuroactive ligand-receptor interaction - Homo sapiens (human)Thyroid hormone signaling pathway - Homo sapiens (human)Generic Transcription PathwaySUMOylationSUMO E3 ligases SUMOylate target proteinsNuclear Receptor transcription pathwayMetabolism of proteinsSUMOylation of intracellular receptorsPost-translational protein modificationRNA Polymerase II Transcription
via MyGene.info
Gene · Ensembl
thyroid hormone receptor alpha
- Symbol
- THRA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:40,058,290-40,093,867
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein THRA PDB 1nav.png
Show 6 more facts
- HomoloGene ID
- 37747
- exact match
- identifiers.org/ncbigene/7067
- genomic end
- 38250120
- genomic start
- 38214543
- cytogenetic location
- 17q21.1
- Commons category
- Thyroid hormone receptor alpha
via Wikidata · CC0
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