kendomycin

Kendomycin is an anticancer macrolide first isolated from Streptomyces violaceoruber. It has potent activity as an endothelin receptor antagonist and anti-osteoporosis agent. It also has strong cytotoxicity against various tumor cell lines.

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Vinony's link graph records 3 inbound references to kendomycin, and connects out to Wayback Machine, digital object identifier and chemical formula.

It sits within the topics Antibiotics, Macrolides and Quinone methides.

Vinony links it to 6 Wikipedia language editions.

Chemical data

Formula: C29H42O6
Molecular weight: 486.6 g/mol
IUPAC name: (1R,9S,10S,12S,14E,16S,19R,20R,21S,22R)-3,9,21-trihydroxy-5,10,12,14,16,20,22-heptamethyl-23,24-dioxatetracyclo[17.3.1.16,9.02,7]tetracosa-2,5,7,14-tetraen-4-one
SMILES: C[C@H]\1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C3=C(C(=O)C(=C4C3=C[C@@](O4)([C@H](C[C@@H](C/C(=C1)/C)C)C)O)C)O)C)O)C
InChIKey: HKLDUJXJTQJSEJ-OLXNOMCWSA-N
XLogP: 4
Polar surface area: 96.2 Å²
H-bond donors: 3
H-bond acceptors: 6
Formal charge: 0

via PubChem

Drug data · ChEMBL

Molecule type: Small molecule

via ChEMBL · EBI

Wikidata facts

Mass: 486.298139

Show 3 more facts

chemical formula: C₂₉H₄₂O₆
isomeric SMILES: C[C@H]\1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C3=C(C(=O)C(=C4C3=C[C@@](O4)([C@H](C[C@@H](C/C(=C1)/C)C)C)O)C)O)C)O)C
canonical SMILES: CC1CCC2C(C(C(C(O2)C3=C(C(=O)C(=C4C3=CC(O4)(C(CC(CC(=C1)C)C)C)O)C)O)C)O)C

Sources (1)

wikidata.org

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

Total synthesis
References

==Total synthesis== Because of its potent biological activities, kendomycin has attracted interest as a target of total synthesis. The first total synthesis of kendomycin was accomplished by Lee and Yuan in 2004. The total number of syntheses stands at 6.

Excerpted from Wikipedia’s “kendomycin” article, available under the CC BY-SA 4.0 licence.