KIRREL1

Also known as NEPH1, KIRREL, kin of IRRE like (Drosophila), Kin of IRRE-like protein 1, kirre like nephrin family adhesion molecule 1, NPHS23

Kin of IRRE-like protein 1, also known as NEPH1, is a protein that in humans is encoded by the KIRREL gene.

Gene data

KIRREL1

Name: kirre like nephrin family adhesion molecule 1
Type: protein-coding
Position: 157,993,273–158,100,262 (+)
Aliases: KIRREL, NEPH1, NPHS23
Ensembl: ENSG00000183853
RefSeq RNA: NM_001286349.2, NM_018240.7, XM_005245305.6, XM_047424310.1, XM_047424312.1
RefSeq protein: NP_001273278.1, NP_060710.3, XP_005245362.1, XP_047280266.1, XP_047280268.1

NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM, Mar 2008].