KIRREL2

Also known as FILTRIN, NEPH3, NLG1, kin of IRRE like 2 (Drosophila), kirre like nephrin family adhesion molecule 2

Kin of IRRE-like protein 2, also known as NEPH3, is a protein that in humans is encoded by the KIRREL2 gene. It is primarily expressed in β cells of the pancreatic islets.

In the Vinony graph

Within Vinony's link graph, KIRREL2 is referenced by 5 other articles, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 19.

Its subject is documented across 5 Wikipedia language editions.

Gene data

KIRREL2

Name: kirre like nephrin family adhesion molecule 2
Type: protein-coding
Position: 35,851,369–35,867,145 (+)
Aliases: FILTRIN, NEPH3, NLG1
Ensembl: ENSG00000126259
RefSeq RNA: NM_001329530.2, NM_001363667.2, NM_032123.7, NM_199179.4, NM_199180.4
RefSeq protein: NP_001316459.1, NP_001350596.1, NP_115499.5, NP_954648.3, NP_954649.3

This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016].

Gene Ontology

Biological process

cell adhesion cell-cell adhesion

Molecular function

protein binding identical protein binding identical protein binding cell adhesion molecule binding

Cellular component

plasma membrane plasma membrane plasma membrane plasma membrane cell-cell junction cell-cell junction cell-cell junction membrane

Pathways

Cell-Cell communication Nephrin family interactions Primary focal segmental glomerulosclerosis (FSGS)

via MyGene.info

Gene · Ensembl

kirre like nephrin family adhesion molecule 2

Symbol: KIRREL2
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:35,851,369-35,867,145
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 35249
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/84063
genomic end: 35867136
genomic start: 36346763
chromosome: human chromosome 19
cytogenetic location: 19q13.12
expressed in: cingulate gyrus

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Kin of IRRE-like protein 2, also known as NEPH3, is a protein that in humans is encoded by the KIRREL2 gene. It is primarily expressed in β cells of the pancreatic islets.

KIRREL2 is a member of the NEPH protein family, which includes NEPH1 (KIRREL) and NEPH2 (KIRREL3).

Excerpted from Wikipedia’s “KIRREL2” article, available under the CC BY-SA 4.0 licence.