LASP1

Also known as MLN50, LIM and SH3 protein 1, LASP-1

LIM and SH3 domain protein 1 is a protein that in humans is encoded by the LASP1 gene.

Gene data

LASP1

Name: LIM and SH3 protein 1
Type: protein-coding
Position: 38,869,185–38,921,771 (+)
Aliases: Lasp-1, MLN50
Ensembl: ENSG00000002834
RefSeq RNA: NM_001271608.2, NM_006148.4, NR_073384.2, XM_047435965.1
RefSeq protein: NP_001258537.1, NP_006139.1, XP_047291921.1

This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012].

Gene Ontology

Biological process

monoatomic ion transport monoatomic ion transport

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Article

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Further reading

LIM and SH3 domain protein 1 is a protein that in humans is encoded by the LASP1 gene.

This gene encodes a member of a LIM protein subfamily which is characterized by a LIM motif and a domain of Src homology region 3. This protein functions as an actin-binding protein and possibly in cytoskeletal organization.