THAP1
Sign in to saveAlso known as DYT6, THAP domain containing, apoptosis associated protein 1, THAP domain containing 1
THAP domain-containing protein 1 is a protein that in humans is encoded by the THAP1 gene. The synonyme is DYT6 (Dystonia 6).
Gene data
THAP1- Name
- THAP domain containing 1
- Type
- protein-coding
- Aliases
- DYT6
The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
THAP domain containing 1
- Symbol
- THAP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:42,836,249-42,843,364
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein THAP1 PDB 2JTG.png
Show 5 more facts
- HomoloGene ID
- 10005
- exact match
- identifiers.org/ncbigene/55145
- genomic end
- 42698468
- genomic start
- 42691817
- cytogenetic location
- 8p11.21
via Wikidata · CC0
~1 min read
Article
6 sectionsContents
- Function
- Interactions
- Clinical significance
- References
- Further reading
- External links
THAP domain-containing protein 1 is a protein that in humans is encoded by the THAP1 gene. The synonyme is DYT6 (Dystonia 6).
== Function ==