THAP1
Sign in to saveAlso known as DYT6, THAP domain containing, apoptosis associated protein 1, THAP domain containing 1
THAP domain-containing protein 1 is a protein that in humans is encoded by the THAP1 gene. The synonyme is DYT6 (Dystonia 6).
In the Vinony graph
Within Vinony's link graph, THAP1 is referenced by 6 other articles, and connects out to PubMed, Ensembl genome database project and protein.
It is catalogued under the topic Genes on human chromosome 8.
Its subject is documented across 5 Wikipedia language editions.
Gene data
THAP1- Name
- THAP domain containing 1
- Type
- protein-coding
- Position
- 42,836,249–42,843,364 (−)
- Aliases
- DYT6
- Ensembl
- ENSG00000131931
- RefSeq RNA
- NM_018105.3, NM_199003.2
- RefSeq protein
- NP_060575.1, NP_945354.1
The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
THAP domain containing 1
- Symbol
- THAP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:42,836,249-42,843,364
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein THAP1 PDB 2JTG.png
Show 8 more facts
- HomoloGene ID
- 10005
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/55145
- genomic end
- 42698468
- genomic start
- 42691817
- chromosome
- human chromosome 8
- cytogenetic location
- 8p11.21
- expressed in
- ganglionic eminence
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Interactions
- Clinical significance
- References
- Further reading
- External links
THAP domain-containing protein 1 is a protein that in humans is encoded by the THAP1 gene. The synonyme is DYT6 (Dystonia 6).
== Function ==
Excerpted from Wikipedia’s “THAP1” article, available under the CC BY-SA 4.0 licence.