leflunomide
Also known as HWA 486, HWA-486, lefunamide, SU-101, alpha,alpha,alpha-trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide, 5-methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide, 5-methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide, alpha,alpha,alpha-trifluoro-5-methyl-4-isoxazolecarboxy-P-toluidide
Leflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug (DMARD), used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase.
Key facts
- Drug.verifiedrevid
- 462089809
- Drug.image
- Leflunomide.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Leflunomide ball-and-stick model.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Arava, Lefumide, Arabloc, others
- Drug.MedlinePlus
- a600032
- Drug.licence_EU
- yes
- Drug.DailyMedID
- Leflunomide
- Drug.pregnancy_AU
- X
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- L04
- Drug.ATC_suffix
Article
10 sectionsContents
- Medical use
- Contraindications
- Adverse effects
- Interactions
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Leflunomide metabolism
- References
- Further reading
Leflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug (DMARD), used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase.
right|thumb|Bottle of Leflunomide (Arava) and tablet