LHX2

Also known as LH2, hLhx2, LIM homeobox 2

LIM/homeobox 2 protein (LHX2) is a protein that in humans is encoded by the LHX2 gene and is part of the LIM gene family. LHX2, like other members of the LIM-homeobox gene family, regulates developmental processes like tissue patterning, cell fate determination and differentiation.

Gene data

LHX2

Name: LIM homeobox 2
Type: protein-coding
Position: 124,001,670–124,033,301 (+)
Aliases: LH2, hLhx2
Ensembl: ENSG00000106689
RefSeq RNA: NM_004789.4, XM_006717323.4, XM_047424082.1, XM_054364178.1, XM_054364179.1
RefSeq protein: NP_004780.3, XP_006717386.1, XP_047280038.1, XP_054220153.1, XP_054220154.1

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of transcription by RNA polymerase II neuron differentiation negative regulation of gene expression, epigenetic positive regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II negative regulation of neurogenesis

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding chromatin binding

Cellular component

chromatin nucleus nucleus

Pathways

Developmental Biology Signaling by ROBO receptors Olfactory Signaling Pathway Axon guidance Regulation of expression of SLITs and ROBOs Nervous system development Sensory Perception Expression and translocation of olfactory receptors Neural Crest Differentiation

via MyGene.info

Gene · Ensembl

LIM homeobox 2

Symbol: LHX2
Biotype: Protein coding
Organism: Homo sapiens
Location: 9:124,001,670-124,033,301
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein LHX2 PDB 2dmq.png

Show 8 more facts

HomoloGene ID: 55848
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/9355
genomic end: 126795580
genomic start: 126763949
chromosome: human chromosome 9
cytogenetic location: 9q33.3
expressed in: amygdala

Sources (3)

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~1 min read

Encyclopedic overview

4 sections

Contents

Structure
Functions
References
Further reading

== Structure == LHX2 as part of the LIM gene family, it encodes for proteins with two N-terminal zinc-finger-like motifs called LIM domains and a homeobox domain. Due to the presence of the LIM domains which bind to zinc, LHX2 can form complexes like with LDB1 in mammals or binding with DNA through the HOX domain to activate genes.

Excerpted from Wikipedia’s “LHX2” article, available under the CC BY-SA 4.0 licence.

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