Structure via PubChem · Public domain (PubChem)
linezolid
Sign in to saveAlso known as U-100766, Zyvox, N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide, Linezolide, Linezolidum
Linezolid is an antibiotic used for the treatment of infections caused by Gram-positive bacteria that are resistant to other antibiotics. Linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA). The main uses are infections of the skin and pneumonia although it may be used for a variety of other infections including drug-resistant tuberculosis. It is used either by injection into a vein or by mouth.
Key facts
- Drug.pregnancy_AU
- B3
- Drug.verifiedrevid
- 850189766
- Drug.image
- Linezolid.svg
- Drug.image_class
- skin-invert-image
- Drug.alt
- Skeletal formula of linezolid
- Drug.image2
- Linezolid-from-xtal-2008-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Zyvox, Zyvoxam, others
- Drug.MedlinePlus
- a602004
- Drug.DailyMedID
- Linezolid
- Drug.routes_of_administration
- Intravenous infusion, by mouth
- Drug.class
- Oxazolidinone antibiotic
- Drug.ATC_prefix
- J01
- Drug.ATC_suffix
- XX08
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C16H20FN3O4
- Molecular weight
- 337.35 g/mol
- IUPAC name
- N-[[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
- SMILES
- CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCOCC3)F
- InChIKey
- TYZROVQLWOKYKF-ZDUSSCGKSA-N
- XLogP
- 0.7
- Polar surface area
- 71.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Research
10,045 papers- Linezolid-associated serotonin toxicity: a systematic review.European journal of clinical pharmacology · 2023
- Linezolid and serotonin syndrome.The Journal of international medical research · 2025
- Linezolid pharmacokinetics: a systematic review for the best clinical practice.European journal of clinical pharmacology · 2023
- Linezolid: a review of its properties, function, and use in critical care.Drug design, development and therapy · 2018
- Linezolid optic neuropathy.Current opinion in ophthalmology · 2023
via PubMed
~41 min read
Encyclopedic overview
25 sectionsContents
- Medical uses
- Skin and soft tissue infections
- Pneumonia
- Other
- Infections of the central nervous system
- Catheter-related infections
- Specific populations
- Spectrum of activity
- Gram-negative bacteria
- Comparable antibiotics
- Adverse effects
- Long-term use
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- Synthesis
- Resistance
- Mechanism
- History
- Society and culture
- Economics
- Brand names
- References
{{Infobox drug | Verifiedfields = | Watchedfields = | verifiedrevid = 850189766 | image = Linezolid.svg | image_class = skin-invert-image | width = | alt = Skeletal formula of linezolid | image2 = Linezolid-from-xtal-2008-3D-balls.png | image_class2 = bg-transparent | width2 = | alt2 = | caption =
| pronounce = | tradename = Zyvox, Zyvoxam, others | Drugs.com = | MedlinePlus = a602004 | DailyMedID = Linezolid | pregnancy_AU = B3 | pregnancy_AU_comment = | pregnancy_category= | routes_of_administration = Intravenous infusion, by mouth | class = Oxazolidinone antibiotic | ATC_prefix = J01 | ATC_suffix = XX08 | ATC_supplemental =
Excerpted from Wikipedia’s “linezolid” article, available under the CC BY-SA 4.0 licence.