MANF

Also known as ARMET, ARP, arginine-rich, mutated in early-stage tumors, arginine-rich protein, mesencephalic astrocyte-derived neurotrophic factor, mesencephalic astrocyte derived neurotrophic factor

Mesencephalic astrocyte-derived neurotrophic factor (MANF), Arginine-rich, mutated in early-stage tumors (ARMET), or arginine-rich protein (ARP) is a protein that in humans is encoded by the MANF housekeeping gene.

Gene data

MANF

Name: mesencephalic astrocyte derived neurotrophic factor
Type: protein-coding
Position: 51,385,291–51,389,397 (+)
Aliases: ARMET, ARP, DDDS
Ensembl: ENSG00000145050
RefSeq RNA: NM_006010.6
RefSeq protein: NP_006001.5

The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014].

Gene Ontology

Biological process

neuron projection development ATF6-mediated unfolded protein response dopaminergic neuron differentiation regulation of response to endoplasmic reticulum stress

Molecular function

RNA binding protein binding growth factor activity growth factor activity sulfatide binding

Cellular component

extracellular region extracellular region extracellular region nucleus endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum lumen cytosol

Pathways

Hemostasis Platelet degranulation Platelet activation, signaling and aggregation Response to elevated platelet cytosolic Ca2+

via MyGene.info

Gene · Ensembl

mesencephalic astrocyte derived neurotrophic factor

Symbol: MANF
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:51,385,255-51,389,802
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein MANF PDB 2KVD.png

Show 5 more facts

HomoloGene ID: 4383
exact match: identifiers.org/ncbigene/7873
genomic start: 51385291
genomic end: 51426828
cytogenetic location: 3p21.2

Sources (4)

via Wikidata · CC0

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Contents

References
External links
Further reading

This gene encodes a highly conserved protein whose function is known. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of a specific mutation changing the previously numbered codon 50 from ATG to AGG, or deletion of that codon, has been reported in a variety of solid tumors. With the protein size correction, this codon is now identified as the initiation codon.