MDFI
Sign in to saveAlso known as MyoD family inhibitor, I-MF, I-mfa
MyoD family inhibitor is a protein that in humans is encoded by the MDFI gene.
Gene data
MDFI- Name
- MyoD family inhibitor
- Type
- protein-coding
- Position
- 41,636,840–41,654,246 (+)
- Aliases
- I-MF, I-mfa
- Ensembl
- ENSG00000112559
- RefSeq RNA
- NM_001300804.2, NM_001300805.2, NM_001300806.2, NM_005586.4, XM_005249117.4
- RefSeq protein
- NP_001287733.1, NP_001287734.1, NP_001287735.1, NP_005577.1, XP_005249174.1
This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
MyoD family inhibitor
- Symbol
- MDFI
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:41,636,840-41,654,250
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 21150
- exact match
- identifiers.org/ncbigene/4188
- genomic end
- 41654244
- genomic start
- 41604620
- cytogenetic location
- 6p21.1
Sources (3)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- Interactions
- References
- Further reading
MyoD family inhibitor is a protein that in humans is encoded by the MDFI gene.
== Function ==