myogenin
Sign in to saveAlso known as MYOG, myogenic factor 4, bHLHc3, Myf-4, class C basic helix-loop-helix protein 3
Myogenin, is a transcriptional activator encoded by the MYOG gene. Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development or myogenesis and repair. Myogenin is a myogenic regulatory factor (MRF), other examples of which also include MyoD, Myf5, and MRF4.
Protein · UniProt
Myogenin
- Gene
- MYOG
- Organism
- Homo sapiens (Human)
- Length
- 224 aa
- Molecular mass
- 25,037 Da
- Evidence
- 1: Evidence at protein level
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, p…
Swiss-Prot (reviewed) · via UniProt
Research
4,098 papers- Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis.Seminars in cell & developmental biology · 2017
- Myogenin Regulates DUSP13 to Inhibit Apoptosis Induced by Reactive Oxygen Species.Frontiers in bioscience (Landmark edition) · 2024
- Myogenin controls via AKAP6 non-centrosomal microtubule-organizing center formation at the nuclear envelope.eLife · 2021
- Myogenin and MyoD1 expression in paediatric rhabdomyosarcomas.Journal of clinical pathology · 2003
- MyoD1 and myogenin expression in human neoplasia: a review and update.Advances in anatomic pathology · 2002
via PubMed
Wikidata facts
- Instance of
- protein
Show 3 more facts
- cell component
- nucleoplasm
- exact match
- purl.uniprot.org/uniprot/P15173
- found in taxon
- Homo sapiens
via Wikidata · CC0
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Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Myogenin, is a transcriptional activator encoded by the MYOG gene. Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development or myogenesis and repair. Myogenin is a myogenic regulatory factor (MRF), other examples of which also include MyoD, Myf5, and MRF4.
In mice, myogenin is essential for the development of functional skeletal muscle. Myogenin is required for the proper differentiation of most myogenic precursor cells during the process of myogenesis. When the DNA coding for myogenin was knocked out of the mouse genome, severe skeletal muscle defects were observed. Mice lacking both copies of myogenin (homozygous-null) suffer from perinatal lethality due to the lack of mature secondary skeletal muscle fibers throughout the body.
Excerpted from Wikipedia’s “myogenin” article, available under the CC BY-SA 4.0 licence.