Structure via PubChem · Public domain (PubChem)
Melfalan
Sign in to saveAlso known as MLP673, Alkeran®, CB-3025, L-phenylalanine mustard (L-PAM), L-sarcolysine, Sarcolysin®, Phenylalanine nitrogen mustard
senyawa kimia
In the Vinony graph
Within Vinony's link graph, Melfalan is referenced by 325 other articles, and connects out to chemotherapy, intravenous infusion and defusion and mechlorethamine.
It sits within the topics Chloroethyl compounds, Drugboxes which contain changes to watched fields and Drugs with non-standard legal status.
Its subject is documented across 28 Wikipedia language editions.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 462248349
- Drug.image
- Melphalan.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 240
- Drug.image2
- Melphalan ball-and-stick.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Alkeran, Evomela, Hepzato, Ivra, Phelinun, others
- Drug.MedlinePlus
- a682220
- Drug.DailyMedID
- Melphalan
- Drug.routes_of_administration
- By mouth, intravenous, intra-arterial
- Drug.ATC_prefix
- L01
- Drug.ATC_suffix
- AA03
- Drug.legal_AU
- S4
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.bioavailability
- 25–89% (By mouth)
- Drug.metabolism
- Hydrolysis to inactive metabolites
via Wikipedia infobox
Chemical data
- Formula
- C13H18Cl2N2O2
- Molecular weight
- 305.2 g/mol
- IUPAC name
- (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
- SMILES
- C1=CC(=CC=C1C[C@@H](C(=O)O)N)N(CCCl)CCCl
- InChIKey
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N
- XLogP
- -0.5
- Polar surface area
- 66.6 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1964
- Admin. routes
- oral, parenteral
- Indications
- multiple myeloma, carcinoma, cutaneous melanoma, neoplasm
via ChEMBL · EBI
Research
12,432 papers- Melphalan Flufenamide (Melflufen): First Approval.Drugs · 2021
- Melphalan: Recent insights on synthetic, analytical and medicinal aspects.European journal of medicinal chemistry · 2022
- Melphalan hydrochloride for the treatment of multiple myeloma.Expert opinion on pharmacotherapy · 2017
- Melphalan and its role in the management of patients with multiple myeloma.Expert review of anticancer therapy · 2007
- Melphalan.Report on carcinogens : carcinogen profiles · 2011
via PubMed
Wikidata facts
- Mass
- 304.074533
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₃H₁₈Cl₂N₂O₂
- subject has role
- carcinogen
- canonical SMILES
- C1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCCl
- isomeric SMILES
- C1=CC(=CC=C1C[C@@H](C(=O)O)N)N(CCCl)CCCl
- World Health Organisation international non-proprietary name
- melphalan
- Commons category
- Melphalan
- legal status (medicine)
- boxed warning
Sources (8)
via Wikidata · CC0
Gallery (3)
Connections
chemotherapy
Entity
intravenous infusion and defusion
Entity
mechlorethamine
Entity
nitrogen mustard
Entity
antineoplastic
Entity
tiazofurin
Entity
World Health Organization
Entity
cancer
Entity
deoxyribonucleic acid
Entity
International Standard Book Number
Entity
kidney
Entity
allergy
Entity
ribonucleic acid
Entity
public domain
Entity
digital object identifier
Entity
infection
Entity
chemical formula
Entity
bone marrow
Entity
hydrochloric acid
Entity
ester
Entity