mesocarb

Mesocarb, sold under the brand name Sidnocarb or Sydnocarb and known by the developmental code name MLR-1017, is a psychostimulant medication which has been used in the treatment of psychiatric disorders and for a number of other indications in the Soviet Union and Russia. It is currently under development for the treatment of Parkinson's disease and sleep disorders. It is taken by mouth.

Research

108 papers

Metabolism of mesocarb in the rat.Xenobiotica; the fate of foreign compounds in biological systems · 1979
Inhibition of dopamine uptake by a new psychostimulant mesocarb (Sydnocarb).Polish journal of pharmacology and pharmacy · 1981
Identification of free and conjugated metabolites of mesocarb in human urine by LC-MS/MS.Analytical and bioanalytical chemistry · 2010
Identification of an intact sydnonimine ring depending on the reaction substituents of mesocarb by gas chromatography/mass spectrometry.Journal of mass spectrometry : JMS · 1999
Synthesis and characterization of hydroxylated mesocarb metabolites for doping control.Archiv der Pharmazie · 2009

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Wikidata facts

Mass: 322.142975816

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chemical formula: C₁₈H₁₈N₄O₂
canonical SMILES: CC(CC1=CC=CC=C1)[N+]2=NOC(=C2)N=C(NC3=CC=CC=C3)[O-]

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Article

15 sections

Contents

Medical uses
Available forms
Pharmacology
Pharmacodynamics
Pharmacokinetics
Chemistry
Synthesis
History
Society and culture
Names
Status
Research
Parkinson's disease
See also
References

The drug is a selective dopamine reuptake inhibitor (DRI). It is an unusual and unique DRI, acting as a negative allosteric modulator and non-competitive inhibitor of the dopamine transporter (DAT). Chemically, mesocarb contains amphetamine within its structure but has been modified and extended at the amine with a sydnone imine-containing moiety.