metergoline

Also known as FI-6337, liserdol, metergoline phenylmethyl ester, D-8-beta-((Carboxyamino)methyl)-1,6-dimethylergoline benzyl ester, Metergolin, D-8-beta-((Carbobenzoxyamino)methyl)-1,6-dimethyl-10-alpha-ergoline, (+)-N-(Carboxy)-1-methyl-9,10-dihydrolysergamine benzyl ester, 1-Methyl-N-carbobenzyloxydihydro-D-lysergamin

Metergoline (, ), also known as methergoline and sold under the brand names Contralac (veterinary) and Liserdol (clinical), is a monoaminergic medication of the ergoline group which is used as a prolactin inhibitor in the treatment of hyperprolactinemia (high prolactin levels) and to suppress lactation.

Research

1,099 papers

Metergoline Shares Properties with Atypical Antipsychotic Drugs Identified by Gene Expression Signature Screen.Neurotoxicity research · 2023
Metergoline-induced cell death in Candida krusei.Fungal biology · 2011
Metergoline inhibits the neuronal Nav1.2 voltage-dependent Na(+) channels expressed in Xenopus oocytes.Acta pharmacologica Sinica · 2014
Endocrine profile and therapeutic employment of a new prolactin-lowering drug, metergoline.Gynecologic and obstetric investigation · 1980
Molecular basis involved in the blocking effect of antidepressant metergoline on C-type inactivation of Kv1.4 channel.Neuropharmacology · 2019

via PubMed

Wikidata facts

Mass: 403.225977

Show 4 more facts

chemical formula: C₂₅H₂₉N₃O₂
isomeric SMILES: CN1C[C@@H](C[C@H]2[C@H]1CC3=CN(C4=CC=CC2=C34)C)CNC(=O)OCC5=CC=CC=C5
canonical SMILES: CN1CC(CC2C1CC3=CN(C4=CC=CC2=C34)C)CNC(=O)OCC5=CC=CC=C5
World Health Organisation international non-proprietary name: metergoline

Sources (3)

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