methylparaben

Also known as nipagin, INS No. 218, INS number 218, E 218, Methyl parahydroxybenzoate, FEMA No. 2710, p-carbomethoxyphenol, p-methoxycarbonylphenol

thumb|right|UV-visible spectrum of methylparaben

Chemical data

Formula: C8H8O3
Molecular weight: 152.15 g/mol
IUPAC name: methyl 4-hydroxybenzoate
SMILES: COC(=O)C1=CC=C(C=C1)O
InChIKey: LXCFILQKKLGQFO-UHFFFAOYSA-N
XLogP: 2
Polar surface area: 46.5 Å²
H-bond donors: 1
H-bond acceptors: 3
Formal charge: 0

via PubChem

Research

1,307 papers

Methylparaben and propylparaben promote bladder cancer invasion via MMP2 and PPARG modulation.Ecotoxicology and environmental safety · 2025
Unraveling the Mechanisms of Osteoporosis Triggered by Methylparaben and Monomethyl Phthalate through Integrated Mendelian Randomization, In Silico Simulations, and Experimental Validation.Environmental science & technology · 2026
Methylparaben-induced regulation of estrogenic signaling in human neutrophils.Molecular and cellular endocrinology · 2021
Methylparaben toxicity and its removal by microalgae Chlorella vulgaris and Phaeodactylum tricornutum.Journal of hazardous materials · 2023
Methylparaben as a preservative in the development of a multi-dose HPV-2 vaccine.Human vaccines & immunotherapeutics · 2022

via PubMed

Wikidata facts

Mass: 152.047

Show 5 more facts

chemical formula: C₈H₈O₃
canonical SMILES: COC(=O)C1=CC=C(C=C1)O
MCN code: 2918.29.22
melting point: 127
Commons category: Methylparaben

Sources (4)

via Wikidata · CC0

~3 min read

Article

5 sections

Contents

Natural occurrences
Uses
Safety
References
External links

thumb|right|UV-visible spectrum of methylparaben

Methylparaben (methyl paraben) one of the parabens, is a preservative with the chemical formula . It is the methyl ester of p-hydroxybenzoic acid. Several related esters are known (ethyl-, propyl-, butylparaben). Together they are the most common preservatives in cosmetics and foods. Among their advantages, parabens are inexpensive, colorless, stable, odorless, and readily biodegraded.