microsome
Sign in to saveAlso known as microsomes
In cell biology, microsomes are heterogeneous vesicle-like artifacts (~20-200 nm diameter) re-formed from pieces of the endoplasmic reticulum (ER) when eukaryotic cells are broken-up in the laboratory; microsomes are not present in healthy, living cells.
Research
90,214 papers- Microsome-associated lumenal lipid droplets in the regulation of lipoprotein secretion.Current opinion in lipidology · 2013
- ER Microsome Preparation in Arabidopsis thaliana.Methods in molecular biology (Clifton, N.J.) · 2018
- Anti-liver-kidney microsome antibody is a marker for the rat hepatocyte endoplasmic reticulum.Hepatology (Baltimore, Md.) · 1987
- Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomes.Journal of pharmaceutical sciences · 2011
- Microsome-mediated oxidation of N-nitrosodiethanolamine (NDELA), a bident carcinogen.Chemical research in toxicology · 2002
via PubMed
~9 min read
Article
7 sectionsContents
- Signal hypothesis
- Cell-free protein synthesis
- Pulse-Chase experiments
- MTP
- See also
- References
- External links
In cell biology, microsomes are heterogeneous vesicle-like artifacts (~20-200 nm diameter) re-formed from pieces of the endoplasmic reticulum (ER) when eukaryotic cells are broken-up in the laboratory; microsomes are not present in healthy, living cells.
Rough (containing ribosomes) and smooth (without ribosomes) microsomes are made from the endoplasmic reticulum through cell disruption. These microsomes have an inside that is exactly the same as the endoplasmic reticulum lumen. Both forms of microsomes can be purified by a process known as equilibrium density centrifugation. Rough and smooth microsomes do differ in their proteins and rough microsomes have shown occurrence of translation and translocation at the same time besides certain exceptions from proteins in yeast.