Structure via PubChem · Public domain (PubChem)
medrogestone
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Medrogestone, sold under the brand name Colprone among others, is a progestin medication which has been used in menopausal hormone therapy and in the treatment of gynecological disorders. It is available both alone and in combination with an estrogen. It is taken by mouth.
Chemical data
- Formula
- C23H32O2
- Molecular weight
- 340.5 g/mol
- IUPAC name
- (8R,9S,10R,13S,14S,17S)-17-acetyl-6,10,13,17-tetramethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one
- SMILES
- CC1=C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@]3(C)C(=O)C)C)[C@@]4(C1=CC(=O)CC4)C
- InChIKey
- HCFSGRMEEXUOSS-JXEXPEPMSA-N
- XLogP
- 4.1
- Polar surface area
- 34.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
142 papers- Use of progestogens and the risk of intracranial meningioma: national case-control study.BMJ (Clinical research ed.) · 2024
- Classification and pharmacology of progestins.Maturitas · 2003
- The effects of estradiol valerate plus medroxyprogesterone acetate and conjugated estrogens plus medrogestone on climacteric symptoms and metabolic variables in perimenopausal women.Acta obstetricia et gynecologica Scandinavica · 1996
- Medrogestone and an LHRH analogue as potential combination therapy for hormone-dependent cancers.Archives of andrology · 1982
- [Tibolone].Presse medicale (Paris, France : 1983) · 2002
via PubMed
Wikidata facts
- Mass
- 340.24023
- Has use
- medication
Show 4 more facts
- chemical formula
- C₂₃H₃₂O₂
- canonical SMILES
- CC1=CC2C(CCC3(C2CCC3(C)C(=O)C)C)C4(C1=CC(=O)CC4)C
- isomeric SMILES
- CC1=C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@]3(C)C(=O)C)C)[C@@]4(C1=CC(=O)CC4)C
- Commons category
- Medrogestone
Sources (2)
via Wikidata · CC0
~9 min read
Encyclopedic overview
16 sectionsContents
- Medical uses
- Contraindications
- Side effects
- Overdose
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- Synthesis
- History
- Society and culture
- Generic names
- Brand names
- Availability
- References
Medrogestone, sold under the brand name Colprone among others, is a progestin medication which has been used in menopausal hormone therapy and in the treatment of gynecological disorders. It is available both alone and in combination with an estrogen. It is taken by mouth.
Medrogestone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has weak antiandrogenic, glucocorticoid, and antimineralocorticoid activity and no other important hormonal activity. Due to its progestogenic activity, medrogestone has antigonadotropic effects.
Excerpted from Wikipedia’s “medrogestone” article, available under the CC BY-SA 4.0 licence.