safinamide
Sign in to saveAlso known as EMD 1195686, EMD-1195686, Xadago®, Xadago
Safinamide, sold under the brand name Xadago among others, is a medication used as treatment for Parkinson's disease with "off" episodes; it has multiple modes of action, including the inhibition of monoamine oxidase B.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 464386010
- Drug.image
- Safinamide.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 250
- Drug.image2
- Safinamide_3D_Xtal.png
- Drug.width2
- 230
- Drug.tradename
- Xadago, others
- Drug.pregnancy_category
- Fetal malformations in animal studies
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- N04
- Drug.ATC_suffix
- BD03
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
via Wikipedia infobox
~9 min read
Encyclopedic overview
11 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Overdose
- Interactions
- Pharmacology
- Mechanisms of action
- Pharmacokinetics
- History
- Research
- References
{{Infobox drug | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 464386010 | image = Safinamide.svg | image_class = skin-invert-image | width = 250 | alt = | image2 = Safinamide_3D_Xtal.png | width2 = 230 | tradename = Xadago, others | Drugs.com = | pregnancy_AU = | pregnancy_category = Fetal malformations in animal studies | routes_of_administration = By mouth | ATC_prefix = N04 | ATC_suffix = BD03 | ATC_supplemental = | legal_AU = S4 | legal_AU_comment = | legal_CA = Rx-only | legal_CA_comment = | legal_UK = POM | legal_UK_comment = | legal_US = Rx-only | legal_US_comment = | legal_EU = Rx-only | legal_EU_comment = | legal_status = | bioavailability = 95% | protein_bound = 88–90% | metabolism = Amidases, glucuronidation | metabolites = | onset = | elimination_half-life = 20–30 hrs | duration_of_action = | excretion = 76% Kidney, 1.5% faeces
| index2_label = mesylate | CAS_number_Ref = | CAS_number = 133865-89-1 | CAS_number2 = 202825-46-5 | PubChem = 131682 | DrugBank_Ref = | DrugBank = DB06654 | IUPHAR_ligand = 8291 | ChEBI = 134718 | ChemSpiderID_Ref = | ChemSpiderID = 116349 | UNII_Ref = | UNII = 90ENL74SIG | ChEMBL_Ref = | ChEMBL = 396778 | ChEMBL2 = 48582 | KEGG = D10158 | KEGG_Ref = | KEGG2 = D10191 | KEGG2_Ref = | synonyms = EMD-1195686, PNU-15774E;(2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl] methylamino]propanamide
Excerpted from Wikipedia’s “safinamide” article, available under the CC BY-SA 4.0 licence.